• in the absence of STING activation, mice show no significant differences in the frequencies of thymocytes, splenic T cells, and splenic myeloid cells relative to control mice
• splenocytes show normal frequencies of CD3+ (T cells), CD19+ (B cells) and CD3- (non-T non-B cells) relative to CD45+ cells; normal CD4+ and CD8+ T cells relative to total CD3+ cells; normal central memory and effector memory CD4+ and CD8+ T cells; and normal FoxP3+ CD4+ regulatory T cells (Tregs)
• moreover, splenocytes show normal frequencies of Ly6G+CD11b+ neutrophils relative to total CD3- splenocytes; normal Ly6Chi CD11b+ monocytes relative to total Ly6G- splenocytes; and normal F4/80midCD11b+ macrophages and F4/80hiCD11b- red pulp macrophages relative to total Ly6Clo splenocytes
• thymocytes show normal frequencies of double-negative (DN), double-positive (DP), and single-positive CD4 and CD8 T cells and normal frequencies of DN subsets