Stat3^tm1Dlv
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Dlv
• Name: signal transducer and activator of transcription 3; targeted mutation 1, David E Levy
• MGI ID: MGI:2384272
• Synonyms: STAT3^f, Stat3^fl, STAT3^flox
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Dlv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78088
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 16 through 21 were flanked by loxP sites inserted by homologous recombination. The floxed region contains sequence encoding portions of the DNA-binding and SH2 domains common to alpha and beta isoforms. (J:53586, J:78088)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stat3^tm1Dlv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:78088 Lee CK, et al., STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002 Jul;17(1):63-72
• All: 83 reference(s)