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Functional Annotation using the Gene Ontology (GO)
MGI's GO project provides functional annotations for mouse gene products using the Gene Ontology.
Access Data
Browse the Gene Ontology and mouse annotations in MGI.
GO Browser
Search for genes using GO terms and other gene attributes.
Genes & Markers Query
Obtain sets of MGI IDs for use in GO tools.
Batch Query
Use GO annotations to discover what your gene set may have in common:
MouseMine - Search for and analyze Gene Ontology results with MouseMine's customized and iterative queries, enrichment analysis and programmatic access.
VLAD - Gene List Analysis and Visualization.
How do I...
.. download all mouse GO annotations? FAQ
.. find all GO annotations for a specific mouse gene? FAQ
.. find all mouse genes with shared annotation to a GO term? FAQ
.. find shared function for a list of specific mouse genes? FAQ
.. view annotations for mouse/human/rat homolog sets? FAQ
More FAQs
Functional Annotations (GO) Data Includes
MGI-Mouse Functional Annotation using the Gene Ontology (GO): About GO - Functional Annotation using the Gene Ontology (GO): About
The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium (www.geneontology.org). MGI fully incorporates the GO in the database and provides a GO browser.

What is a Gene Ontology annotation?

Gene Ontology annotation is a manually or automatically assigned text file containing the following information:

  • Gene name, symbol
  • Gene Ontology term
  • Published reference
  • Evidence code
  • Date of the annotation
  • Optional information (Qualifiers such as "NOT", "contributes_to", "colocalizes_with"; Notes with both free text and controlled vocabulary information)

What is manual annotation?

Scientific curators use published literature to assign GO terms based on evidence codes, which support the annotation. See also the Guide to GO Evidence Codes at the Gene Ontology Consortium site.

What are evidence codes?

MGI uses the following evidence codes:

  • Manually assigned:
    • EXP - Inferred from experiment
    • IAS - Inferred from ancestral sequence
    • IBA - Inferred from biological aspect of ancestor
    • IBD - Inferred from biological aspect of descendant
    • IC - Inferred by curator
    • IDA - Inferred from direct assay
    • IEP - Inferred from expression pattern
    • IGI - Inferred from genetic interaction
    • IKR - Inferred from key residues
    • IMP - Inferred from mutant phenotype
    • IMR - Inferred from missing residues
    • IPI - Inferred from physical Interaction
    • IRD - Inferred from rapid divergence
    • ISA - Inferred from sequence alignment
    • ISM - Inferred from sequence model
    • ISO - Inferred from sequence orthology
    • ISS - Inferred from sequence and structural similarity
    • ND - Not determined
    • TAS - Traceable author statement
  • Automatically assigned:
    • IEA - Inferred from electronic annotation
    • HDA - inferred from high throughput direct assay
    • HEP - inferred from high throughput expression pattern
    • HGI - inferred from high throughput genetic interaction
    • HMP - inferred from high throughput mutant phenotype
    • RCA - Reviewed computational analysis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory