Zbtb7b^tm6.1Itan
Targeted Allele Detail

Summary

• Symbol: Zbtb7b^tm6.1Itan
• Name: zinc finger and BTB domain containing 7B; targeted mutation 6.1, Ichiro Taniuchi
• MGI ID: MGI:5506929
• Synonyms: Thpok^Sfl
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^tm6.1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195348
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the 5' silencer region and a floxed neo cassette was inserted immediately downstream. Transient cre expression removed the selection cassette from properly targeted ES cells leaving the silencer region flanked by loxP sites. (J:195348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 26 strains or lines available

References

• Original: J:195348 Tanaka H, et al., Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus. EMBO J. 2013 Apr 17;32(8):1183-94
• All: 2 reference(s)