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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7btm6.1Itan
targeted mutation 6.1, Ichiro Taniuchi
MGI:5506929
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd8a-cre)1Itan/? 		involves: C57BL/6 MGI:5506931
cn2
 		Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd4-cre)1Cwi/? 		involves: C57BL/6 * DBA/2 MGI:5506930


Genotype
MGI:5506931
cn1
Allelic
Composition		 Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd8a-cre)1Itan/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd8a-cre)1Itan mutation (2 available)
Zbtb7btm6.1Itan mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:195348 )
N
• CD8+ T cell development is normal




Genotype
MGI:5506930
cn2
Allelic
Composition		 Zbtb7btm6.1Itan/Zbtb7btm6.1Itan
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (12 available)
Zbtb7btm6.1Itan mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:195348 )
• loss of peripheral CD8+ T cells

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:195348 )
• loss of peripheral CD8+ T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory