Eomes^tm1Srnr
Targeted Allele Detail

Summary

• Symbol: Eomes^tm1Srnr
• Name: eomesodermin; targeted mutation 1, Steven Reiner
• MGI ID: MGI:3802572
• Synonyms: Eomes^2F, Eomes^Exon1-fl, Eomes^F
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm1Srnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137655
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Germ line, cre-mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:137655)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 41 strains or lines available

References

• Original: J:137655 Intlekofer AM, et al., Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science. 2008 Jul 18;321(5887):408-11
• All: 25 reference(s)