Cd79atm1(cre)Reth
Targeted Allele Detail
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Symbol: |
Cd79atm1(cre)Reth |
Name: |
CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth |
MGI ID: |
MGI:3687451 |
Synonyms: |
Cd79a-, Cd79a-Cre, mb1-cre, mb.1-Cre, mb1Cre, Mb-1Cre |
Gene: |
Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
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Alliance: |
Cd79atm1(cre)Reth page
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Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:113645
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
BALB/c
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutation: |
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Insertion
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Cd79atm1(cre)Reth expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cd79a (MGI:101774) |
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Mutation details: Exons 2 and 3 of the Cd79a gene were replaced with a cDNA encoding a mammalian codon-optimized cre (hCre) followed by an SV40 poly(A) signal. Exon 1 was truncated to remove the Cd79a ATG start codon, and a tk-neo cassette flanked by FRT sites was introduced 3' to hCre. The neo cassette was deleted in chimeras by crossing to Flpe deleter mice.
(J:113645, J:135783)
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Generation of the floxed Atmintm1.2Jhh allele |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cd79a
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:113645 Hobeika E, et al., Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94 |
All: |
336 reference(s) |
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