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Cd79atm1(cre)Reth
Targeted Allele Detail
Summary
Symbol: Cd79atm1(cre)Reth
Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth
MGI ID: MGI:3687451
Synonyms: Cd79a-, Cd79a-Cre, mb1-cre, mb.1-Cre, mb1Cre, Mb-1Cre
Gene: Cd79a  Location: Chr7:24596922-24601283 bp, + strand  Genetic Position: Chr7, 13.49 cM
Alliance: Cd79atm1(cre)Reth page
Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113645
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Cd79atm1(cre)Reth expression driven by 1 gene
 
Mutation detailsExons 2 and 3 of the Cd79a gene were replaced with a cDNA encoding a mammalian codon-optimized cre (hCre) followed by an SV40 poly(A) signal. Exon 1 was truncated to remove the Cd79a ATG start codon, and a tk-neo cassette flanked by FRT sites was introduced 3' to hCre. The neo cassette was deleted in chimeras by crossing to Flpe deleter mice. (J:113645, J:135783)
Generation of the floxed Atmintm1.2Jhh allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd79a (mouse)
Summary of all recombinase alleles driven by Cd79a.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 9 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Cd79atm1(cre)Reth
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cd79a Mutation:  22 strains or lines available
References
Original:  J:113645 Hobeika E, et al., Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94
All:  338 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory