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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd79atm1(cre)Reth
targeted mutation 1, Michael Reth
MGI:3687451
Summary 67 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Cd79atm1(cre)Reth/Cd79a+ involves: BALB/c * C57BL/6 MGI:3687461
cn2
Atmintm1.1Jhh/Atmintm1.1Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
B6.Cg-Bcl2l11tm1.1Ast Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri MGI:5755464
cn3
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh MGI:5755460
cn4
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri MGI:5755462
cn5
Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak MGI:5314905
cn6
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth MGI:5755454
cn7
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Tg(IghMyc)22Bri/0
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri MGI:5755458
cn8
Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
involves: 129 * BALB/c MGI:6717461
cn9
Grk2tm1Gwd/Grk2tm1Gwd
Cd79atm1(cre)Reth/Cd79a+
involves: 129 * BALB/c * C57BL/6 MGI:5295055
cn10
Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Nr4a3em1Juz/Nr4a3em1Juz
involves: 129 * BALB/c * C57BL/6 MGI:6717460
cn11
Cd79atm1(cre)Reth/Cd79a+
Inpp5dtm1Rav/Inpp5dtm1Rav
involves: 129 * BALB/c * C57BL/6 MGI:6376530
cn12
Inpp5dtm1Rav/Inpp5dtm1Rav
Cd79atm1(cre)Reth/Cd79a+
Tg(IghAb36-65)1Wys/0
involves: 129 * BALB/c * C57BL/6 * FVB/N MGI:6376533
cn13
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Cd79atm1(cre)Reth/Cd79a+
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL MGI:5698683
cn14
Srsf3tm1Pjln/Srsf3tm1Pjln
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c MGI:3687458
cn15
Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5463974
cn16
Cd79atm1(cre)Reth/Cd79a+
Eif4a1tm1.1Bea/Eif4a1tm1.1Bea
involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:7646987
cn17
Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3797235
cn18
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N MGI:4440609
cn19
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL MGI:6358358
cn20
Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL MGI:5795709
cn21
Cd79atm1(cre)Reth/Cd79a+
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL MGI:5698681
cn22
Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5314906
cn23
Cd79atm1(cre)Reth/Cd79a+
Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J MGI:6112652
cn24
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
involves: 129S1/Sv * BALB/c MGI:3797396
cn25
Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
involves: 129S1/Sv * BALB/c * C57BL/6 MGI:5463975
cn26
Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Cd79atm1(cre)Reth/Cd79a+
involves: 129S2/SvPas * BALB/c * C57BL/6J MGI:5578118
cn27
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:6294908
cn28
Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:6294907
cn29
Dnmt1tm2Jae/Dnmt1tm2Jae
Cd79atm1(cre)Reth/Cd79a+
involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:3687459
cn30
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+
involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:5462351
cn31
Cnn2tm1.1Jin/Cnn2tm1.1Jin
Cnn3tm1.1Hjum/Cnn3tm1.1Hjum
Cd79atm1(cre)Reth/Cd79a+
involves: 129S6/SvEvTac * 129X1/SvJ * BALB/c MGI:5825469
cn32
Cnn3tm1.1Hjum/Cnn3tm1.1Hjum
Cd79atm1(cre)Reth/Cd79a+
involves: 129S6/SvEvTac * BALB/c MGI:5825467
cn33
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
involves: 129S6/SvEvTac * BALB/c * C57BL/6J MGI:5301627
cn34
Ssbtm1Rjma/Ssbtm2.1Rjma
Cd79atm1(cre)Reth/Cd79a+
involves: 129S/SvEv * BALB/c MGI:5569496
cn35
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129X1/SvJ * BALB/c * C57BL/6 MGI:3687456
cn36
Dicer1tm1Mmk/Dicer1tm1.1Mmk
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:3797392
cn37
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:3797393
cn38
Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:5295256
cn39
Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:5295253
cn40
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(IghelMD4)4Ccg/0
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:3797394
cn41
Grb2tm1Lnit/Grb2tm1Lnit
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * BALB/cJ MGI:4949890
cn42
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:3687508
cn43
Cd79atm1(cre)Reth/Cd79a+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
involves: BALB/c * C57BL/6 MGI:5501491
cn44
Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5574306
cn45
Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5463972
cn46
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+
involves: BALB/c * C57BL/6 MGI:5319486
cn47
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y
involves: BALB/c * C57BL/6 MGI:5319485
cn48
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn
involves: BALB/c * C57BL/6 MGI:5319484
cn49
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5825357
cn50
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5008568
cn51
Stim1tm1Kuro/Stim1tm1Kuro
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5008567
cn52
Stim1tm1Kuro/Stim1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 MGI:5008566
cn53
Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Tg(IghelMD4)4Ccg/0
involves: BALB/c * C57BL/6 * C57BL/6J MGI:7611733
cn54
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * C57BL/6JJcl MGI:5461328
cn55
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2 MGI:5461331
cn56
Cd79atm1(cre)Reth/Cd79a+
Eif4btm1.1Tnr/Eif4btm1.1Tnr
Eif4htm1c(EUCOMM)Wtsi/Eif4htm1c(EUCOMM)Wtsi
involves: BALB/c * C57BL/6 * C57BL/6N MGI:7646989
cn57
Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
involves: BALB/c * C57BL/6J MGI:7625698
cn58
Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
involves: BALB/c * C57BL/6J MGI:7611716
cn59
Cd79atm1(cre)Reth/Cd79a+
Orai3em1.1Treb/Orai3em1.1Treb
involves: BALB/c * C57BL/6J * C57BL/6N MGI:7625703
cn60
Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb
involves: BALB/c * C57BL/6J * C57BL/6N MGI:7625702
cn61
Cd79atm1(cre)Reth/Cd79a+
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(BCL2)22Wehi/0
involves: BALB/c * C57BL/6JWehi * SJL/JWehi MGI:3797395
cn62
Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj MGI:5550380
cn63
Cd79atm1(cre)Reth/Cd79a+
Commd3tm1.1Ksuz/Commd3tm1.1Ksuz
involves: BALB/c * C57BL/6NSlc * SJL MGI:6358355
cn64
Cd79atm1(cre)Reth/Cd79a+
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
involves: BALB/c * C57BL/6NSlc * SJL MGI:6358356
cn65
Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * NZB MGI:5296787
cn66
Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
involves: BALB/c * C57BL/6 * NZB MGI:5296788
cn67
Ebf1tm1.1Rug/Ebf1tm1.1Rug
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * SJL MGI:5316371


Genotype
MGI:3687461
ht1
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• numbers of cells in B subfractions in spleen and bone marrow is unchanged vs wild-type




Genotype
MGI:5755464
cn2
Allelic
Composition
Atmintm1.1Jhh/Atmintm1.1Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Bcl2l11tm1.1Ast Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (2 available); any Atmin mutation (38 available)
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (34 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• compared with Tg(IghMyc)22Bri mice




Genotype
MGI:5755460
cn3
Allelic
Composition
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (2 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 8-fold in the peripheral blood
• 10-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice

hematopoietic system
• 8-fold in the peripheral blood
• 10-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice

cellular




Genotype
MGI:5755462
cn4
Allelic
Composition
Atmintm1.1Jhh/Atmintm1.1Jhh
Cd79atm1(cre)Reth/Cd79a+
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Cd79atm1(Cre)Reth Atmintm1.1Jhh Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (2 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 7.5-fold compared with Tg(IghMyc)22Bri mice
• 60-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice

neoplasm
• compared with Tg(IghMyc)22Bri mice
• compared with Tg(IghMyc)22Bri mice
• however, the range to tumor types is the same

cellular

hematopoietic system
• 7.5-fold compared with Tg(IghMyc)22Bri mice
• 60-fold compared with Cd79atm1(Cre)Reth/Cd79a+ or Tg(IghMyc)22Bri mice




Genotype
MGI:5314905
cn5
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Genetic
Background
B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in pre-B cells and mature B cells (1.5-fold)
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
• partially blocked at pre-B stage
• following stimulation of B cells with LPS or LPS plus IL4
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
• virtually absent in the peritoneal cavity
• due to increased apoptosis
• mice stimulated with a T-independent antigen, TNP-Ficoll, fail to mount a TNP-specific IgM or IgG3 unlike control mice
• mice stimulated with a T-dependent antigen, NP(15)CGG, produce less NP-specific IgG1 compared with control mice
• 4.5-fold in unstimulated mice
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
• 32-fold in unstimulated mice
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
• mice infected with vesicular stomatitis virus (VSV) exhibit delayed anti-VSV antibody production and reduced anti-VSV IgG levels compared with control mice

cellular
• in pre-B cells and mature B cells (1.5-fold)
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4

hematopoietic system
• in pre-B cells and mature B cells (1.5-fold)
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
• partially blocked at pre-B stage
• following stimulation of B cells with LPS or LPS plus IL4
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
• virtually absent in the peritoneal cavity
• due to increased apoptosis
• 4.5-fold in unstimulated mice
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
• 32-fold in unstimulated mice
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll




Genotype
MGI:5755454
cn6
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic
Background
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dynll1tm1.1Jhh mutation (4 available); any Dynll1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 2-fold in pro-B/pre-B
• 8-fold in the bone marrow
• 4-fold in the spleen
• in the bone marrow

hematopoietic system
• 2-fold in pro-B/pre-B
• 8-fold in the bone marrow
• 4-fold in the spleen
• in the bone marrow




Genotype
MGI:5755458
cn7
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dynll1tm1.1Jhh mutation (4 available); any Dynll1 mutation (20 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• greater than 50-fold

neoplasm
• compared with Tg(IghMyc)22Bri mice

hematopoietic system
• greater than 50-fold




Genotype
MGI:6717461
cn8
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Genetic
Background
involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)




Genotype
MGI:5295055
cn9
Allelic
Composition
Grk2tm1Gwd/Grk2tm1Gwd
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Grk2tm1Gwd mutation (1 available); any Grk2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the lymph nodes
• in the spleen and blood
• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells
• long-term accumulation of B cells in the lymph node is reduced compared with control cells
• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells
• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells
• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice
• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells
• however, transfer into a S1P null mouse restores normal lymph node accumulation

hematopoietic system
• in the lymph nodes
• in the spleen and blood
• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells
• long-term accumulation of B cells in the lymph node is reduced compared with control cells
• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells
• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells
• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice
• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells
• however, transfer into a S1P null mouse restores normal lymph node accumulation




Genotype
MGI:6717460
cn10
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Nr4a3em1Juz/Nr4a3em1Juz
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
Nr4a3em1Juz mutation (0 available); any Nr4a3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

hematopoietic system
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

immune system
N
• normal T cell and B cell development and homeostasis
• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)
• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)




Genotype
MGI:6376530
cn11
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Inpp5dtm1Rav/Inpp5dtm1Rav
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Inpp5dtm1Rav mutation (1 available); any Inpp5d mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have a less than 40% survival rate at 1 year

immune system
• IgG deposition in kidney glomeruli is seen at 20 weeks of age
• mice show autoantibodies that are specifically seen in lupus; ssDNA, dsDNA, dsRNA and chromatin
• anti-nuclear antibodies in the sera in 20-week old mice
• mice exhibit chromatin autoantibodies at 8 weeks of age and at 20 weeks of age, mice show chromatin antibodies at amounts comparable to those seen in NZB/NZW mice

hematopoietic system
• IgG deposition in kidney glomeruli is seen at 20 weeks of age




Genotype
MGI:6376533
cn12
Allelic
Composition
Inpp5dtm1Rav/Inpp5dtm1Rav
Cd79atm1(cre)Reth/Cd79a+
Tg(IghAb36-65)1Wys/0
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Inpp5dtm1Rav mutation (1 available); any Inpp5d mutation (93 available)
Tg(IghAb36-65)1Wys mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
• increase in frequency of plasma cells in the B cell population (4.96% of B cells compared to 0.04% in controls)
• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
• cell surface mIgM and mIgD are reduced 50% in B cells and B cells express reduced CD93, CD95, and CD80 indicating a loss of anergic B cells
• B cells lose features of anergy, including antigen unresponsiveness measured by BCR aggregation-induced Akt activation and calcium mobilization
• increase in frequency of B cells with activated phenotype (CD86+)
• mice spontaneously express about 4-fold increased autoantibody by 20 weeks of age

hematopoietic system
• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
• increase in frequency of plasma cells in the B cell population (4.96% of B cells compared to 0.04% in controls)
• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection




Genotype
MGI:5698683
cn13
Allelic
Composition
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Cd79atm1(cre)Reth/Cd79a+
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ikzf1tm3.1Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (119 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• three fold fewer pro-B cells

immune system
• three fold fewer pro-B cells




Genotype
MGI:3687458
cn14
Allelic
Composition
Srsf3tm1Pjln/Srsf3tm1Pjln
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Srsf3tm1Pjln mutation (0 available); any Srsf3 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• strong reduction in number of B cell precursors is seen in bone marrow
• drastic reductions in B cell number are found in spleen, thymus, and bone marrow
• drastic reduction in pre-B cells indicates that Sfrs3 is required for pre-B cell survival

hematopoietic system
• strong reduction in number of B cell precursors is seen in bone marrow
• drastic reductions in B cell number are found in spleen, thymus, and bone marrow
• drastic reduction in pre-B cells indicates that Sfrs3 is required for pre-B cell survival




Genotype
MGI:5463974
cn15
Allelic
Composition
Atmintm1.2Jhh/Atmintm1.2Jhh
Trp53tm1Brn/Trp53tm1Brn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
• in the spleen but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• in the bone marrow but not as severe as in Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:7646987
cn16
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Eif4a1tm1.1Bea/Eif4a1tm1.1Bea
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Eif4a1tm1.1Bea mutation (0 available); any Eif4a1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• greater than 20-fold reduction in pro B or Hardy Fraction B cells in the bone marrow
• remaining pro B cells have only a minor reduction in EIF4A1 and a 10-fold increase in EIF4A2
• almost complete loss of splenic B cells

immune system
• greater than 20-fold reduction in pro B or Hardy Fraction B cells in the bone marrow
• remaining pro B cells have only a minor reduction in EIF4A1 and a 10-fold increase in EIF4A2
• almost complete loss of splenic B cells




Genotype
MGI:3797235
cn17
Allelic
Composition
Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Syktm1Kuro mutation (0 available); any Syk mutation (42 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a complete block pro-B cell differentation at the BP-1+HASlow stage

hematopoietic system
• there is a complete block pro-B cell differentation at the BP-1+HASlow stage




Genotype
MGI:4440609
cn18
Allelic
Composition
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Hdac1tm1.1Pmt mutation (0 available); any Hdac1 mutation (37 available)
Hdac2tm1.1Pmt mutation (0 available); any Hdac2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• of pre BII cells and large pre BII cells
• numbers of pre BI cells are reduced by 60%-80%
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
• only a very few B cells remain
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
• fewer than 1% of pre BII cell stage cells remain
• virtually empty of circulating mature B cells

immune system
• of pre BII cells and large pre BII cells
• numbers of pre BI cells are reduced by 60%-80%
• block in B cell differentiation as early as the pre BI cell stage only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
• fewer than 1% of pre BII cell stage cells remain
• virtually empty of circulating mature B cells

cellular
• of pre BII cells and large pre BII cells




Genotype
MGI:6358358
cn19
Allelic
Composition
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Commd8tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
Ightm1Mnz mutation (4 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours

hematopoietic system
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours




Genotype
MGI:5795709
cn20
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ctnnbl1tm1.1Crad mutation (0 available); any Ctnnbl1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal splenic B cells numbers and early stages of B cell differentiation
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
• in response to LPS or anti-CD40 stimulation
• reduced immunoglobin class switching in splenic B cells

hematopoietic system
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
• in response to LPS or anti-CD40 stimulation
• reduced immunoglobin class switching in splenic B cells

cellular
• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells
• in response to LPS or anti-CD40 stimulation




Genotype
MGI:5698681
cn21
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ikzf1tm3.1Mbu mutation (0 available); any Ikzf1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
• six fold reduction in total B cell number in bone marrow relative to controls
• nearly complete loss of pre-B cells

neoplasm
N
• evidence of B cell leukemias is not observed during a year of observation

immune system
• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
• six fold reduction in total B cell number in bone marrow relative to controls
• nearly complete loss of pre-B cells




Genotype
MGI:5314906
cn22
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (63 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• bone marrow B cell development and stimulated and unstimulated splenic B cell proliferation are restored compared to in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
• virtually absent in the peritoneal cavity

hematopoietic system
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
• virtually absent in the peritoneal cavity




Genotype
MGI:6112652
cn23
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Slc39a10tm1.1Tfk mutation (0 available); any Slc39a10 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3797396
cn24
Allelic
Composition
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (34 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Bcl2l11tm1.1Ast/Bcl2l11+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice

hematopoietic system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Bcl2l11tm1.1Ast/Bcl2l11+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice




Genotype
MGI:5463975
cn25
Allelic
Composition
Atmintm1.2Jhh/Atmintm1.2Jhh
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (34 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• B cell development is rescued compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

hematopoietic system
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice

growth/size/body
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice
• compared with control and Atmintm1.2Jhh/Atmintm1.2Jhh Cd79atm1(cre)Reth/Cd79a+ mice




Genotype
MGI:5578118
cn26
Allelic
Composition
Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tbc1d10ctm1.1Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tbc1d10ctm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• accelerated antigen-specific B cell response in vivo in response to ovalbumin
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• in ovalbumin-treated mice
• CpG-DNA-treated mice exhibit increased anti-double stranded DNA antibody levels and renal IgG deposits compared with control mice
• in CpG-DNA-treated mice
• however, untreated mice do not produce autoantibodies

hematopoietic system
• accelerated antigen-specific B cell response in vivo in response to ovalbumin
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
• in ovalbumin-treated mice




Genotype
MGI:6294908
cn27
Allelic
Composition
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Mzb1tm1.1Rug mutation (0 available); any Mzb1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased percentage of B220+ CD43+ pro-B cells in bone marrow
• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow
• decrease in CD19+ B cells in splenic B cell compartment
• reduced frequency of peritoneal B cells
• reduced percentage of B220hi CD43- recirculating B cells in bone marrow
• reduced percentage of B220int CD43- pre-B cells in bone marrow
• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures
• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures
• reduced CD25+ pre-B cell number in bone marrow

immune system
• increased percentage of B220+ CD43+ pro-B cells in bone marrow
• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow
• decrease in CD19+ B cells in splenic B cell compartment
• reduced frequency of peritoneal B cells
• reduced percentage of B220hi CD43- recirculating B cells in bone marrow
• reduced percentage of B220int CD43- pre-B cells in bone marrow
• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures
• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures
• reduced CD25+ pre-B cell number in bone marrow




Genotype
MGI:6294907
cn28
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (78 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Mzb1tm1.1Rug mutation (0 available); any Mzb1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 2.5-fold reduction in frequency of muHC+ lambda5+ cells in bone marrow
• increase in lambda5+ only bone marrow cells




Genotype
MGI:3687459
cn29
Allelic
Composition
Dnmt1tm2Jae/Dnmt1tm2Jae
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dnmt1tm2Jae mutation (1 available); any Dnmt1 mutation (110 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is complete block of B cell development in spleen and bone marrow
• proportion of CD19+ lymphocytes is 10% compared to 74% in wild-type

hematopoietic system
• there is complete block of B cell development in spleen and bone marrow
• proportion of CD19+ lymphocytes is 10% compared to 74% in wild-type




Genotype
MGI:5462351
cn30
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Traf3ip2tm2Sbn mutation (0 available); any Traf3ip2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)
• develop glomerulonephritis comparable to single Fcgr2b homozygotes

hematopoietic system
• mutants exhibit an increase in percentage and the total number of germinal center B cells compared to wild-type mice, although the total number of germinal center B cells is lower than in Fcgr2b homozygotes (that are also heterozygous for the floxed Traf3ip2 allele)

renal/urinary system
• develop glomerulonephritis comparable to single Fcgr2b homozygotes




Genotype
MGI:5825469
cn31
Allelic
Composition
Cnn2tm1.1Jin/Cnn2tm1.1Jin
Cnn3tm1.1Hjum/Cnn3tm1.1Hjum
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Cnn2tm1.1Jin mutation (0 available); any Cnn2 mutation (19 available)
Cnn3tm1.1Hjum mutation (1 available); any Cnn3 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal formation of precursor and mature B cell populations




Genotype
MGI:5825467
cn32
Allelic
Composition
Cnn3tm1.1Hjum/Cnn3tm1.1Hjum
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S6/SvEvTac * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Cnn3tm1.1Hjum mutation (1 available); any Cnn3 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal early B cell development




Genotype
MGI:5301627
cn33
Allelic
Composition
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs mutation (0 available); any Gt(ROSA)26Sor mutation (967 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is blocked at pro-B cell stage
• in the spleen, inguinal lymph nodes, and peritoneal cavity

hematopoietic system
• B cell development is blocked at pro-B cell stage
• in the spleen, inguinal lymph nodes, and peritoneal cavity




Genotype
MGI:5569496
cn34
Allelic
Composition
Ssbtm1Rjma/Ssbtm2.1Rjma
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: 129S/SvEv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ssbtm1Rjma mutation (0 available); any Ssb mutation (32 available)
Ssbtm2.1Rjma mutation (0 available); any Ssb mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal splenic CD4+ and CD8+ T cells
• total block at the pro-B cell to pre-B cell transition
• hyposplenia

hematopoietic system
• total block at the pro-B cell to pre-B cell transition
• hyposplenia




Genotype
MGI:3687456
cn35
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background
involves: 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (12 available); any Gt(ROSA)26Sor mutation (967 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 97% of B lineage cells are EYFP-positive compared with 33% in Cd19tm1(cre)Cgn-expressing mice indicating more efficient loxP recombination in developing B cells




Genotype
MGI:3797392
cn36
Allelic
Composition
Dicer1tm1Mmk/Dicer1tm1.1Mmk
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1tm1.1Mmk mutation (0 available); any Dicer1 mutation (94 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• usage of Dh elements and N nucleotide insertion into Igkappa is increased compared to in wild-type mice

hematopoietic system
• usage of Dh elements and N nucleotide insertion into Igkappa is increased compared to in wild-type mice




Genotype
MGI:3797393
cn37
Allelic
Composition
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the bone marrow
• B cell development is almost completely blocked at the pro- to pre-B cell transition
• hardly detected
• in the bone marrow due to a massive increase in apoptosis

hematopoietic system
• in the bone marrow
• B cell development is almost completely blocked at the pro- to pre-B cell transition
• hardly detected
• in the bone marrow due to a massive increase in apoptosis




Genotype
MGI:5295256
cn38
Allelic
Composition
Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (47 available)
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• stimulated B cells exhibit reduced ability to induced T cell proliferation
• from stimulated B cells

hematopoietic system
• stimulated B cells exhibit reduced ability to induced T cell proliferation




Genotype
MGI:5295253
cn39
Allelic
Composition
Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells

immune system
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
• to IgG3 induced by T cell-independent type II antigens
• in the spleen
• 5- to 10-fold in peritoneal washes
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

hematopoietic system
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
• to IgG3 induced by T cell-independent type II antigens
• in the spleen
• 5- to 10-fold in peritoneal washes
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

cellular
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation




Genotype
MGI:3797394
cn40
Allelic
Composition
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(IghelMD4)4Ccg/0
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (94 available)
Tg(IghelMD4)4Ccg mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice

hematopoietic system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice




Genotype
MGI:4949890
cn41
Allelic
Composition
Grb2tm1Lnit/Grb2tm1Lnit
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Grb2tm1Lnit mutation (0 available); any Grb2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in an adoptive transfer experiment, B cells are at a competitive disadvantage to wild-type B cells
• IgM-secreting plasma cells
• in peripheral blood
• mice exhibit a reduction in recirculating, mature (IgM+B220hi fraction F) B cells in the bone marrow compared with Grb2tm1Lnit homozygote controls
• the number of mature B cells in the spleen is half that in wild-type mice
• however, mice exhibit normal numbers of marginal zone B cells and B1 cells in the spleen and peritoneal cavity
• in mice immunized with sheep red blood cell
• in mice immunized with sheep red blood cell
• mice exhibit reduced Brd-U labeled T1/marginal zone B cells compared with cells from Grb2tm1Lnit homozygote controls
• however, bone marrow pre-B and immature B cell proliferation is normal
• immature and mature B cells exhibit a slight increase in spontaneous apoptosis compared to in Grb2tm1Lnit homozygote controls
• after anti-IgM or LPS stimulation
• in response to secondary exposure to human cytomegalovirus-derived virus-like particles
• however, primary IgG response is normal
• in TNP-ficoll treated mice
• 10-fold in unstimulated mice
• however, IgM response to TNP-ficoll is normal
• mice exhibit impaired memory response to human cytomegalovirus-derived virus-like particles compared with Grb2tm1Lnit homozygote controls

hematopoietic system
• in an adoptive transfer experiment, B cells are at a competitive disadvantage to wild-type B cells
• IgM-secreting plasma cells
• in peripheral blood
• mice exhibit a reduction in recirculating, mature (IgM+B220hi fraction F) B cells in the bone marrow compared with Grb2tm1Lnit homozygote controls
• the number of mature B cells in the spleen is half that in wild-type mice
• however, mice exhibit normal numbers of marginal zone B cells and B1 cells in the spleen and peritoneal cavity
• in mice immunized with sheep red blood cell
• in mice immunized with sheep red blood cell
• mice exhibit reduced Brd-U labeled T1/marginal zone B cells compared with cells from Grb2tm1Lnit homozygote controls
• however, bone marrow pre-B and immature B cell proliferation is normal
• immature and mature B cells exhibit a slight increase in spontaneous apoptosis compared to in Grb2tm1Lnit homozygote controls
• after anti-IgM or LPS stimulation
• in response to secondary exposure to human cytomegalovirus-derived virus-like particles
• however, primary IgG response is normal
• in TNP-ficoll treated mice
• 10-fold in unstimulated mice
• however, IgM response to TNP-ficoll is normal
• mice exhibit impaired memory response to human cytomegalovirus-derived virus-like particles compared with Grb2tm1Lnit homozygote controls

cellular
• immature and mature B cells exhibit a slight increase in spontaneous apoptosis compared to in Grb2tm1Lnit homozygote controls
• after anti-IgM or LPS stimulation




Genotype
MGI:3687508
cn42
Allelic
Composition
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a pronounced block in B cell development at transition stage 1 in the spleen
• mice show dramatic reduction in peripheral B cell numbers
• numbers of mature B cells are reduced to 10% of levels in controls

hematopoietic system
• there is a pronounced block in B cell development at transition stage 1 in the spleen
• mice show dramatic reduction in peripheral B cell numbers
• numbers of mature B cells are reduced to 10% of levels in controls




Genotype
MGI:5501491
cn43
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• lack inflammation up to 30 weeks of age




Genotype
MGI:5574306
cn44
Allelic
Composition
Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn mutation (0 available); any Gt(ROSA)26Sor mutation (967 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slightly less in LPS-stimulated marginal zone
• however, proliferation of alphaIgM-stimulated follicular B cells is not significantly different from that of wild-type cells
• total and FO II B cells

hematopoietic system
• slightly less in LPS-stimulated marginal zone
• however, proliferation of alphaIgM-stimulated follicular B cells is not significantly different from that of wild-type cells
• total and FO II B cells

cellular
• slightly less in LPS-stimulated marginal zone
• however, proliferation of alphaIgM-stimulated follicular B cells is not significantly different from that of wild-type cells




Genotype
MGI:5463972
cn45
Allelic
Composition
Atmintm1.2Jhh/Atmintm1.2Jhh
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.2Jhh mutation (4 available); any Atmin mutation (38 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice

immune system
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
• more than 7-fold in the bone marrow
• more than 7-fold in the spleen
• 3-fold in the bone marrow
• 2-fold
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells

hematopoietic system
• impaired in a cell-intrinsic manner
• not rescued by provision of a prearranged BCR
• more than 7-fold in the bone marrow
• more than 7-fold in the spleen
• 3-fold in the bone marrow
• 2-fold
• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells




Genotype
MGI:5319486
cn46
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Wastm1.1Ldn mutation (0 available); any Was mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations
• while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells
• enrichment of null cells in the germinal center cell and plasma cell populations

hematopoietic system
• increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations
• while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells
• enrichment of null cells in the germinal center cell and plasma cell populations

cellular
• increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations




Genotype
MGI:5319485
cn47
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Wastm1.1Ldn mutation (0 available); any Was mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the spleen and lymph nodes
• increase in the proportion of CD19+ CD138hi plasma cells
• B cell lymphopenia
• decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells
• decrease in the proportion and number of CD19+ B cells in the spleen
• decrease in absolute number but not the proportion of follicular B cells
• decrease in the percentage and absolute number of marginal zone B cells
• the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent
• virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses
• abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus
• elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

renal/urinary system
• modest degree of glomerular damage

hematopoietic system
• in the spleen and lymph nodes
• increase in the proportion of CD19+ CD138hi plasma cells
• B cell lymphopenia
• decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells
• decrease in the proportion and number of CD19+ B cells in the spleen
• decrease in absolute number but not the proportion of follicular B cells
• decrease in the percentage and absolute number of marginal zone B cells
• the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent
• virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses
• abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus
• elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine




Genotype
MGI:5319484
cn48
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Wastm1.1Ldn mutation (0 available); any Was mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the spleen and lymph nodes
• increase in the proportion of CD19+ CD138hi plasma cells
• B cell lymphopenia
• decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells
• decrease in the proportion and number of CD19+ B cells in the spleen
• decrease in absolute number but not the proportion of follicular B cells
• decrease in the percentage and absolute number of marginal zone B cells
• the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent
• virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses
• abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus
• elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

renal/urinary system
• modest degree of glomerular damage

hematopoietic system
• in the spleen and lymph nodes
• increase in the proportion of CD19+ CD138hi plasma cells
• B cell lymphopenia
• decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells
• decrease in the proportion and number of CD19+ B cells in the spleen
• decrease in absolute number but not the proportion of follicular B cells
• decrease in the percentage and absolute number of marginal zone B cells
• the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent
• virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses
• abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus
• elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine




Genotype
MGI:5825357
cn49
Allelic
Composition
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tcf3tm1(PBX1)Mlc mutation (0 available); any Tcf3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop acute leukemia with an incidence of 53% at 12 months of age
• leukemia cells are present in the bone marrow, spleen, lymph nodes and infiltrate multiple organs, including the CNS
• 94% of leukemias have a B cell precursor phenotype

hematopoietic system
• in leukemic mice
• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation
• in leukemic mice
• in leukemic mice
• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice
• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice
• leukemic mice present with leukocytosis

immune system
• in leukemic mice
• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation
• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice
• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice
• leukemic mice present with leukocytosis
• in leukemic mice

liver/biliary system
• in leukemic mice

growth/size/body
• in leukemic mice
• in leukemic mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute lymphoblastic leukemia DOID:9952 OMIM:247640
OMIM:613065
J:226241




Genotype
MGI:5008568
cn50
Allelic
Composition
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Stim2tm1.1Kuro mutation (0 available); any Stim2 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• B cell proliferation in response to anti-IgM, anti-CD40, and LPS is normal
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

homeostasis/metabolism
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

hematopoietic system
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice




Genotype
MGI:5008567
cn51
Allelic
Composition
Stim1tm1Kuro/Stim1tm1Kuro
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Stim1tm1Kuro mutation (0 available); any Stim1 mutation (46 available)
Stim2tm1.1Kuro mutation (0 available); any Stim2 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

immune system
N
• mice exhibit normal B cell development
• following immunization with MOG35-55
• following immunization with MOG35-55
• following immunization with MOG35-55
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
• in splenocytes following immunization with MOG35-55
• following stimulation with PMA and ionomycin, LPS, anti-IgM and anti-CD40, or anti-IgM and LPS
• in splenocytes following immunization with MOG35-55
• in splenocytes following immunization with MOG35-55
• following immunization with MOG35-55, mice exhibit increased inflammatory cells infiltration (CD8+ and CD4+ T cells, T regulatory cells), demyelination, and cytokine production (IFN-gamma, IL17, and IL10) compared with control mice

nervous system
• following immunization with MOG35-55

hematopoietic system
• following immunization with MOG35-55
• following immunization with MOG35-55
• following immunization with MOG35-55
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

cellular
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal




Genotype
MGI:5008566
cn52
Allelic
Composition
Stim1tm1Kuro/Stim1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Stim1tm1Kuro mutation (0 available); any Stim1 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• B cells exhibit less calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

immune system
• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
• B cells exhibit less calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
• following PMA and ionomycin stimulation

hematopoietic system
• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
• B cells exhibit less calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

cellular
• anti-IgM-treated B cells exhibit decreased proliferation unlike control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal




Genotype
MGI:7611733
cn53
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Tg(IghelMD4)4Ccg/0
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Phf5atm1.1Oux mutation (0 available); any Phf5a mutation (18 available)
Tg(IghelMD4)4Ccg mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells

immune system
• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells




Genotype
MGI:5461328
cn54
Allelic
Composition
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny
• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny




Genotype
MGI:5461331
cn55
Allelic
Composition
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice immunized with NP-CG exhibit normal development of memory B cells
• in mice immunized with NP-CG

hematopoietic system
• in mice immunized with NP-CG




Genotype
MGI:7646989
cn56
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Eif4btm1.1Tnr/Eif4btm1.1Tnr
Eif4htm1c(EUCOMM)Wtsi/Eif4htm1c(EUCOMM)Wtsi
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Eif4btm1.1Tnr mutation (0 available); any Eif4b mutation (47 available)
Eif4htm1c(EUCOMM)Wtsi mutation (0 available); any Eif4h mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• 7 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin B cell numbers are similar to immunized controls
• small reduction (25%) in mature/recirculating B cells
• normal numbers of splenic B cells and fractions of B-E B cells in the bone marrow
• small reduction in high-affinity IgG1 antibodies at 14 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin

immune system
• small reduction (25%) in mature/recirculating B cells
• normal numbers of splenic B cells and fractions of B-E B cells in the bone marrow
• small reduction in high-affinity IgG1 antibodies at 14 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin




Genotype
MGI:7625698
cn57
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Genetic
Background
involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Orai1tm1Smua mutation (0 available); any Orai1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no defects in B cell development in the bone marrow or spleen
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• however, agonist induced Ca2+ oscillations are similar to controls
• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• anti-IgM mediated NFAT1 translocation is significantly reduced
• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted

homeostasis/metabolism
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• residual SOCE activity in B cells is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• however, agonist induced Ca2+ oscillations in B cells are similar to controls

hematopoietic system
• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• however, agonist induced Ca2+ oscillations are similar to controls
• anti-IgM mediated NFAT1 translocation is significantly reduced
• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted




Genotype
MGI:7611716
cn58
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Genetic
Background
involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Phf5atm1.1Oux mutation (0 available); any Phf5a mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• defect in RAG-mediated recombination
• significant reduction in the diversity of IgH chain repetoires
• decreased absolute numbers of BP1- CD24+ early pro-B cells
• decreased absolute numbers of BP1+ CD24high late pro-B cells
• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
• no increase in proliferation of pre-pro-B cells
• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
• defect in IgH chain gene expression in pre-pro-B cells

immune system
• defect in RAG-mediated recombination
• significant reduction in the diversity of IgH chain repetoires
• decreased absolute numbers of BP1- CD24+ early pro-B cells
• decreased absolute numbers of BP1+ CD24high late pro-B cells
• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
• no increase in proliferation of pre-pro-B cells
• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
• defect in IgH chain gene expression in pre-pro-B cells




Genotype
MGI:7625703
cn59
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Orai3em1.1Treb/Orai3em1.1Treb
Genetic
Background
involves: BALB/c * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Orai3em1.1Treb mutation (0 available); any Orai3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• store-operated Ca2+ entry in B cells is not significantly different from controls
• anti-IgM stimulated proliferation is similar to control but viability is increased

hematopoietic system
• anti-IgM stimulated proliferation is similar to control but viability is increased




Genotype
MGI:7625702
cn60
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb
Genetic
Background
involves: BALB/c * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Orai1tm1Smua mutation (0 available); any Orai1 mutation (21 available)
Orai3em1.1Treb mutation (0 available); any Orai3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• immune responses to influenza A infection are similar to controls
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

hematopoietic system
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

homeostasis/metabolism
• store-operated Ca2+ entry in B cells is reduced by~83%

cellular
• decrease in both proliferation and viablity of cells following anti-IgM stimulation




Genotype
MGI:3797395
cn61
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(BCL2)22Wehi/0
Genetic
Background
involves: BALB/c * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Dicer1tm1Mmk mutation (0 available); any Dicer1 mutation (94 available)
Tg(BCL2)22Wehi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice

hematopoietic system
• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice




Genotype
MGI:5550380
cn62
Allelic
Composition
Rnf31tm1.1Kiwa/Rnf31tm1.1Kiwa
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Rnf31tm1.1Kiwa mutation (3 available); any Rnf31 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal conventional B cell development and I cell populations
• severely impaired B1 B cell development in the peritoneal cavity
• in the peritoneal cavity
• in the peritoneal cavity
• impaired antibody responses to both T cell-dependent and T cell-independent type 2 antigens
• in unimmunized mice
• in unimmunized mice
• in mice immunized with NP-CGG
• in unimmunized mice
• in unimmunized mice
• in unimmunized mice
• in mice immunized with NP-Ficoll
• in unimmunized mice
• in mice immunized with NP-CGG or NP-Ficoll

hematopoietic system
• severely impaired B1 B cell development in the peritoneal cavity
• in the peritoneal cavity
• in the peritoneal cavity
• in unimmunized mice
• in unimmunized mice
• in mice immunized with NP-CGG
• in unimmunized mice
• in unimmunized mice
• in unimmunized mice
• in mice immunized with NP-Ficoll
• in unimmunized mice
• in mice immunized with NP-CGG or NP-Ficoll




Genotype
MGI:6358355
cn63
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Commd3tm1.1Ksuz/Commd3tm1.1Ksuz
Genetic
Background
involves: BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Commd3tm1.1Ksuz mutation (0 available); any Commd3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal size of developing B cell subsets and serum levels of IgG3 and IgA in unimmunized mice
• in the bone marrow, blood, and spleen
• in the bone marrow, blood, and spleen
• decreased after immunization with NP-CGG compared with controls
• less defined boundaries
• after immunization with NP-CGG compared with controls
• impaired B cell migration in response to CXCL12, CXCL13, CCL19 and 7alpha,25-HC
• bone marrow chimeras exhibit increased migration of B cells from follicles compared with wild-derived cells
• however, response to S1P is normal as is lymph node egression
• in unimmunized mice and after immunization with NP-CGG compared with controls
• in unimmunized mice
• in unimmunized mice
• in unimmunized mice and after immunization with NP-CGG compared with controls

hematopoietic system
• in the bone marrow, blood, and spleen
• in the bone marrow, blood, and spleen
• decreased after immunization with NP-CGG compared with controls
• less defined boundaries