Orai1^tm1Smua
Targeted Allele Detail

Summary

• Symbol: Orai1^tm1Smua
• Name: ORAI calcium release-activated calcium modulator 1; targeted mutation 1, Shmuel Muallem
• MGI ID: MGI:6119518
• Synonyms: Orai1^fl
• Gene: Orai1 Location: Chr5:123153137-123168519 bp, + strand Genetic Position: Chr5, 62.72 cM
• Alliance: Orai1^tm1Smua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250410
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites and a PGK-neo cassette was inserted downstream of exon 3 before the second loxP site. (J:250410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Orai1 Mutation: 21 strains or lines available

References

• Original: J:250410 Ahuja M, et al., Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity. Cell Metab. 2017 Mar 7;25(3):635-646
• All: 7 reference(s)