About   Help   FAQ
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm4(Ikbkb)Rsky
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Klaus Rajewsky
MGI ID: MGI:3687199
Synonyms: Gt(ROSA)26Sortm1(Ikbkb)Mass, R26IKK2casFL, R26StopFLikk2ca, R26StopIkk2SSEE
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm4(Ikbkb)Rsky page
Germline Transmission:  Earliest citation of germline transmission: J:113365
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm4(Ikbkb)Rsky expresses 1 gene
Mutation detailsAn IRES-eGFP cassette and a cDNA sequence encoding Ikbkb containing two serine to glutamate substitutions in the activation loop of the kinase domain, preceded by a floxed stop-neo cassette was inserted into the locus. The Ikbkb would be expressed under the control of the endogenous ROSA26 promoter after cre-mediated excision of the STOP cassette. (J:113365)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 37 assay results
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm4(Ikbkb)Rsky
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  811 strains or lines available
Original:  J:113365 Sasaki Y, et al., Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006 Jun;24(6):729-39
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory