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Transgene Detail
Symbol: Tg(IghMyc)22Bri
Name: transgene insertion 22, Ralph L Brinster
MGI ID: MGI:2447604
Synonyms: Emu-c-myc, Emu-cmyc Tg, Emu-myc, E-myc, Eu-Myc, Tg-IghMyc-22Bri
Transgene: Tg(IghMyc)22Bri  Location: unknown  
Alliance: Tg(IghMyc)22Bri page
Pro-B tumor in Pknox1tm1Ngc/Pknox1+ Tg(IghMyc)22Bri/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(IghMyc)22Bri expresses 1 gene
Mutation detailsExpression of the mouse Myc transgene is directed to the B cell lineage by the Igh (E mu) enhancer and Myc promoter. The transgene was originally designated Eμ-Myc. (J:78177)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(IghMyc)22Bri
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
13 out of 15 transgenic founders developed lymphomas between 6 and 15 weeks of age. The animals became terminally ill and died or were sacrificed.

Hemizygous mice on a C57BL/6 background display increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.

In conjuction with Tg(BCL2)22Wehi, transgenic mice on a C57BL/6 background exhibit the production of primitive lymphoid tumors within 5 weeks of birth

Original:  J:78177 Adams JM, et al., The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985 Dec 12-18;318(6046):533-8
All:  292 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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