Slc39a10^tm1.1Tfk
Targeted Allele Detail

Summary

• Symbol: Slc39a10^tm1.1Tfk
• Name: solute carrier family 39 (zinc transporter), member 10; targeted mutation 1.1, Toshiyuki Fukada
• MGI ID: MGI:5642299
• Synonyms: Zip10^fl
• Gene: Slc39a10 Location: Chr1:46846704-46932012 bp, - strand Genetic Position: Chr1, 24.07 cM
• Alliance: Slc39a10^tm1.1Tfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213932
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-neomycin-loxP cassette was inserted upstream of exon 6 followed by a third loxP site in intron 8. The neomycin cassette was removed in the floxed allele. (J:213932, J:213935)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc39a10 Mutation: 49 strains or lines available

References

• Original: J:213932 Hojyo S, et al., Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91
• All: 4 reference(s)