Nfatc1^tm1Rao
Targeted Allele Detail

Summary

• Symbol: Nfatc1^tm1Rao
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Anjana Rao
• MGI ID: MGI:5295237
• Synonyms: Nfat2^flx, Nfatc1^flx
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^tm1Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. (J:177319, J:190104, J:248991)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 47 strains or lines available

References

• Original: J:177319 Bhattacharyya S, et al., NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med. 2011 Apr 11;208(4):823-39
• All: 21 reference(s)