Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ulrich Siebenlist
• MGI ID: MGI:5574305
• Synonyms: Bcl-3 Tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207111
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL3 (602)

  Bcl3	(MGI:88140)

• Mutation details: The targeting construct introduced into the locus a UbiC promoter driving expression of a Tap-tagged human Bcl3 cDNA with a polyadenylation sequence preceded by a floxed STOP cassette. Flp-mediated recombination removed the neomycin resistance cassette inserted downstream of the polyadenylation sequence. (J:207111)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:207111 Zhang X, et al., The tumor promoter and NF-kappaB modulator Bcl-3 regulates splenic B cell development. J Immunol. 2013 Dec 15;191(12):5984-92
• All: 3 reference(s)