Cnn2^tm1.1Jin
Targeted Allele Detail

Summary

• Symbol: Cnn2^tm1.1Jin
• Name: calponin 2; targeted mutation 1.1, Jian-Ping Jin
• MGI ID: MGI:3820422
• Gene: Cnn2 Location: Chr10:79824434-79831234 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Cnn2^tm1.1Jin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted in introns 1 and 2 an an frt flanked neomycin resistance cassette was inserted downstream of the loxP site in intron 2. Mice were then crossed to Gt(ROSA)26Sor^tm1(FLP1)Dym to produce mice with germline deletion of the frt flanked neomycin resistance cassette. Levels of protein product are restored in these mice. (J:141867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnn2 Mutation: 19 strains or lines available

References

• Original: J:141867 Huang QQ, et al., Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem. 2008 Sep 19;283(38):25887-99
• All: 4 reference(s)