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Bcl6tm1.1Mtto
Targeted Allele Detail
Summary
Symbol: Bcl6tm1.1Mtto
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Toshitada Takemori
MGI ID: MGI:5461311
Synonyms: Bcl6f
Gene: Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance: Bcl6tm1.1Mtto page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190943
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette wiht a 5 loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette and left exons 7 through 9 floxed. (J:190943)
Generation of the Bcl6tm1.1Mtto allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:  55 strains or lines available
References
Original:  J:190943 Kaji T, et al., Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012 Oct 22;209(11):2079-97
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory