Bcl6^tm1.1Mtto
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Mtto
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Toshitada Takemori
• MGI ID: MGI:5461311
• Synonyms: Bcl6^f
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Mtto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190943
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette wiht a 5 loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette and left exons 7 through 9 floxed. (J:190943)

Generation of the Bcl6^tm1.1Mtto allele

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 55 strains or lines available

References

• Original: J:190943 Kaji T, et al., Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012 Oct 22;209(11):2079-97
• All: 27 reference(s)