About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1.1Mtto
targeted mutation 1.1, Toshitada Takemori
MGI:5461311
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl MGI:5461329
cn2
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 * C57BL/6JJcl MGI:5461328
cn3
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0 		involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2 MGI:5461331
cn4
 		Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6JJcl * DBA/2 MGI:5461330


Genotype
MGI:5461329
cn1
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190943 )
N
• mice immunized with NP-CG exhibit normal development of memory B cells
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

hematopoietic system
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells




Genotype
MGI:5461328
cn2
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:190943 )
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
abnormal memory B cell morphology ( J:190943 )
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
abnormal memory B cell physiology ( J:190943 )
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny
abnormal humoral immune response ( J:190943 )
• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system
abnormal somatic hypermutation frequency ( J:190943 )
• memory B cells from mice immunized with NP-CG fail to undergo somatic hypermutation compared with wild-type mice
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 5 and 7 (200-fold)
abnormal memory B cell morphology ( J:190943 )
• early germinal center memory B cells from mice immunized with NP-CG exhibit a resting state compared with wild-type mice
• however, the number of memory B cells is normal
abnormal memory B cell physiology ( J:190943 )
• 40 days after immunization with NP-CG, GC-independent memory B cells arise from dividing precursors, fail to exhibit a decrease in proliferation unlike wild-type cells and enter the memory compartment before germinal B cell progeny




Genotype
MGI:5461331
cn3
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190943 )
N
• mice immunized with NP-CG exhibit normal development of memory B cells
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG

hematopoietic system
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG




Genotype
MGI:5461330
cn4
Allelic
Composition		 Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JJcl * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:190943 )
• in memory B cells from mice immunized with NP-CG
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 40 but not day 7
absent germinal center B cells ( J:190943 )
• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40
decreased T follicular helper cell number ( J:190943 )
• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40
abnormal humoral immune response ( J:190943 )
• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system
abnormal somatic hypermutation frequency ( J:190943 )
• in memory B cells from mice immunized with NP-CG
decreased germinal center B cell number ( J:190943 )
• in mice immunized with NP-CG at day 40 but not day 7
absent germinal center B cells ( J:190943 )
• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40
decreased T follicular helper cell number ( J:190943 )
• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory