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Ighg1tm1(cre)Cgn
Targeted Allele Detail
Summary
Symbol: Ighg1tm1(cre)Cgn
Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne
MGI ID: MGI:3652526
Synonyms: Cgamma1-cre, Cy1-cre, IghC gamma1-cre, Ighg1tm1(IRES-cre)Cgn
Gene: Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance: Ighg1tm1(cre)Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109583
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ighg1tm1(cre)Cgn expression driven by 1 gene
 
Mutation detailsAn IRES-cre was inserted into the 3' region of the Cgamma1 locus between the last membrane-coding exon and its polyadenylation sites. This targeting design allows for the expression from the locus of a bicistronic mRNA consisting of the Cgamma1 and Cre transcript. An FRT site flanked neomycin resistance gene cassette was removed via Flp recombinase expression. (J:109583)
Generation of the Ighg1tm1(cre)Cgn knockin.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ighg1 (mouse)
Summary of all recombinase alleles driven by Ighg1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Ighg1tm1(cre)Cgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:  28 strains or lines available
References
Original:  J:109583 Casola S, et al., Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory