Ighg1^tm1(cre)Cgn
Targeted Allele Detail

Summary

• Symbol: Ighg1^tm1(cre)Cgn
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne
• MGI ID: MGI:3652526
• Synonyms: Cgamma1-cre, Cy1-cre, Igh^C gamma^1-cre, Ighg1^{tm1(IRES-cre)Cgn}
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^tm1(cre)Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109583
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Recombinase) Mutation: Insertion Mutation details: A targeting vector containing an IRES-cre was inserted into the 3' region of the Cgamma1 locus between the last membrane-coding exon and its polyadenylation sites. This targeting design allows for the expression from the locus of a bicistronic mRNA consisting of the Cgamma1 and Cre transcript. An frt-flanked neo was removed via FLP recombinase expression. (J:109583)

Generation of the Ighg1^tm1(cre)Cgn knockin.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ighg1 (mouse) Summary of all recombinase alleles driven by Ighg1. Comparative matrix view of recombinase activities Alliance mouse Ighg1 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 15 strains or lines available

References

• Original: J:109583 Casola S, et al., Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401
• All: 79 reference(s)