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Ighg1tm1(cre)Cgn
Targeted Allele Detail
Summary
Symbol: Ighg1tm1(cre)Cgn
Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, University of Cologne
MGI ID: MGI:3652526
Synonyms: Cgamma1-cre, Cy1-cre, IghC gamma1-cre, Ighg1tm1(IRES-cre)Cgn
Gene: Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance: Ighg1tm1(cre)Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109583
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing an IRES-cre was inserted into the 3' region of the Cgamma1 locus between the last membrane-coding exon and its polyadenylation sites. This targeting design allows for the expression from the locus of a bicistronic mRNA consisting of the Cgamma1 and Cre transcript. An frt-flanked neo was removed via FLP recombinase expression. (J:109583)
Generation of the Ighg1tm1(cre)Cgn knockin.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ighg1 (mouse)
Summary of all recombinase alleles driven by Ighg1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:  15 strains or lines available
References
Original:  J:109583 Casola S, et al., Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/14/2023
MGI 6.22
The Jackson Laboratory