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Targeted Allele Detail
Symbol: Rag2tm1Fwa
Name: recombination activating gene 2; targeted mutation 1, Frederick W Alt
MGI ID: MGI:1858556
Synonyms: Rag2-, RAG-2-, RAG2 KO, Rag2M, Rag2tm1Alt, Rag2tm1Fwe
Gene: Rag2  Location: Chr2:101455063-101462874 bp, + strand  Genetic Position: Chr2, 53.87 cM
Alliance: Rag2tm1Fwa page
Germline Transmission:  Earliest citation of germline transmission: J:1935
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 0.85kb segment of the open reading frame, eliminating the encoding of 286 of the 527 amino acids of the protein. (J:1935)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Rag2tm1Fwa
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 47 strains available      Cell Lines: 0 lines available
Carrying any Rag2 Mutation:  103 strains or lines available
Original:  J:1935 Shinkai Y, et al., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67
All:  945 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory