Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sergei B Koralov
• MGI ID: MGI:3778925
• Synonyms: Gt(ROSA)26Sor^{tm1(STAT3C)Sbkv}, Gt(ROSA)26Sor^{tm1(Stat3*)Sbkv}, Gt(ROSA)26Sor^{tm2(STAT3,EGFP)Cgn}, R26Stat3C^stopfl, Stat3-C^stoplox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133218
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Stat3 (MGI:103038)

• Mutation details: A targeting construct introduced into the locus a floxed neomycin resistance and STOP cassette, the cDNA for a hyperactive version of human Stat3 (A661C and N663C; STAT3C) with a FLAG-tag, and an FRT-flanked IRES-EGFP reporter cassette. In the presence of Cre recombinase, the STOP element is removed and bicistronic expression of STAT3 and GFP occurs. (J:133218)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:133218 Mesaros A, et al., Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab. 2008 Mar;7(3):236-48
• All: 12 reference(s)