Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
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immune system
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• under Th17 conditions, T cells transduced with a cre protein (Tat-Cre) exhibit increased differentiation towards
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hematopoietic system
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• under Th17 conditions, T cells transduced with a cre protein (Tat-Cre) exhibit increased differentiation towards
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Fabp4-cre/ERT2)1Ipc mutation
(0 available)
Tyk2tm1Shmd mutation
(0 available);
any
Tyk2 mutation
(70 available)
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adipose tissue
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• mice exhibit normal brown adipose tissue morphology with reduced body weight compared to single Tyk2 homozygotes
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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mortality/aging
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• however, treatment with anti-IL17A antibodies improves survival
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immune system
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• modest increase in IFNG+ T cells (that also express IL17) indicating a slight expansion of Th1 cells
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• in the peripheral lymph nodes and lungs
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• Th17 cells infiltrate the airways and cause severe neutrophilic lung inflammation with thickening of the airway epithelium, hypertrophy of the smooth muscle surrounding large and midsized airways and pronounced perivascular, increased mucus production and peribronchial/peribronchiolar inflammatory infiltrates
• however, lung phenotype is improved by treatment with anti-IL17A antibodies
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respiratory system
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• Th17 cells infiltrate the airways and cause severe neutrophilic lung inflammation with thickening of the airway epithelium, hypertrophy of the smooth muscle surrounding large and midsized airways and pronounced perivascular, increased mucus production and peribronchial/peribronchiolar inflammatory infiltrates
• however, lung phenotype is improved by treatment with anti-IL17A antibodies
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homeostasis/metabolism
hematopoietic system
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• modest increase in IFNG+ T cells (that also express IL17) indicating a slight expansion of Th1 cells
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• in the peripheral lymph nodes and lungs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
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growth/size/body
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• mice on a normal chow diet weigh 10% less than littermate controls from weaning until 20 weeks of age
• differences are more pronounced when mice are kept on a high fat diet with mice weighing 15-20% less until the age of 20 weeks
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homeostasis/metabolism
adipose tissue
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• mice of either sex on a normal chow diet displayed a 30% reduction in epigonodal fat-pad weight at 20 weeks of age
• mice on a high fat diet displayed a 40-60 % weight reduction in the epigonodal fat pads at 20 weeks of age
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behavior/neurological
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• mice exhibit a slight postpubertal hyperphagia
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• at 9 weeks of age, mice exhibit a dramatic increase in basal locomotor activity with a 40% increase during the light phase and 60% during the dark phase compared to control mice
• mice exhibit the highest locomotor activity at the beginning of the dark cycle where they were more than twice as active as their littermate controls
• there are also greater increases in fasting-induced hyperactivity than in control mice
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Analysis Tools