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Ifngtm1Ts
Targeted Allele Detail
Summary
Symbol: Ifngtm1Ts
Name: interferon gamma; targeted mutation 1, Timothy Stewart
MGI ID: MGI:1857184
Synonyms: gko, GKO, ifgtm1, ifng-, IFN-gamma-, IFNgamma-, IFN-gammaKO, IFN-gamma KO, IFNgamma KO, IFN-gammatm1Ts, IFN-g KO, Ifngtm1Ts, Ifn-gtm1Ts, Ifngtm1Ts, ifntm1Ts, Ifntm/Ts
Gene: Ifng  Location: Chr10:118276951-118281797 bp, + strand  Genetic Position: Chr10, 66.75 cM
Alliance: Ifngtm1Ts page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66802
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. (J:66802)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 16 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ifngtm1Ts
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 18 strains available      Cell Lines: 0 lines available
Carrying any Ifng Mutation:  44 strains or lines available
References
Original:  J:66802 Dalton DK, et al., Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]. Science. 1993 Mar 19;259(5102):1739-42
All:  1175 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory