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Ifng Gene Detail
Summary
  • Symbol
    Ifng
  • Name
    interferon gamma
  • Synonyms
    Ifg, IFN-gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:107656
    NCBI Gene: 15978
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    7 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:118276951-118281797 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 66.75 cM
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107656
 protein coding gene Chr10:118276951-118281799 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017767
 protein coding gene Chr10:121446974-121451811 (+)
A/J MGP_AJ_G0017742
 protein coding gene Chr10:116698303-116703151 (+)
AKR/J MGP_AKRJ_G0017705
 protein coding gene Chr10:120155962-120160811 (+)
BALB/cJ MGP_BALBcJ_G0017706
 protein coding gene Chr10:117083233-117088081 (+)
C3H/HeJ MGP_C3HHeJ_G0017530
 protein coding gene Chr10:120341068-120345917 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018161
 protein coding gene Chr10:125584926-125589771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015842
 protein coding gene Chr10:111086658-111091444 (+)
CAST/EiJ MGP_CASTEiJ_G0017091
 protein coding gene Chr10:120650189-120655027 (+)
CBA/J MGP_CBAJ_G0017499
 protein coding gene Chr10:130638832-130643681 (+)
DBA/2J MGP_DBA2J_G0017605
 protein coding gene Chr10:115812924-115817772 (+)
FVB/NJ MGP_FVBNJ_G0017600
 protein coding gene Chr10:114816910-114821755 (+)
LP/J MGP_LPJ_G0017679
 protein coding gene Chr10:122017312-122022157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017629
 protein coding gene Chr10:133412520-133417364 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018202
 protein coding gene Chr10:120187412-120192257 (+)
PWK/PhJ MGP_PWKPhJ_G0016875
 protein coding gene Chr10:115906481-115911333 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016666
 protein coding gene Chr10:119055933-119060726 (+)
WSB/EiJ MGP_WSBEiJ_G0017151
 protein coding gene Chr10:120372727-120377572 (+)



Homology
more
  • Human Ortholog
    IFNG, interferon gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNG, interferon gamma
  • Synonyms
    IFG, IFI, IMD69
  • Links
    NCBI Gene ID: 3458
    neXtProt AC: NX_P01579
    UniProt: P01579

  • Chr Location
    12q15; chr12:68154768-68159740 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ifng mouse models; 28 with human IFNG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    165 phenotypes from 6 alleles in 23 genetic backgrounds
    121 phenotypes from multigenic genotypes
    1402 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    152
  • GO References
    66
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    108
  • cDNA Data
    15
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055170 Ensembl Gene Model | MGI Sequence Detail 4847 C57BL/6J ±  kb
    transcript ENSMUST00000068592 Ensembl | MGI Sequence Detail 1208 Not Applicable  
    polypeptide ENSMUSP00000063800 Ensembl | MGI Sequence Detail 155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 16
      Primer pair 8
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11214, MGD-MRK-36231
    References
    more
    • Summaries
      All 2260
      Developmental Gene Expression 32
      Diseases 7
      Gene Ontology 66
      Phenotypes 1402
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory