medulloblastoma Disease Ontology Browser

Disease Ontology Browser

medulloblastoma (DOID:0050902)
Alliance: disease page
Synonyms: brain medulloblastoma; CNS PNET; CPNET; infratentorial primitive neuroectodermal tumor; localized primitive neuroectodermal tumor; Medulloblastoma, histologically defined
Alt IDs: OMIM:155255, DOID:0060105, DOID:168, DOID:3858, DOID:4981, MESH:D008527, MESH:D018242, NCI:C27294, NCI:C3222, NCI:C3716, ORDO:616, UMLS_CUI:C0025149, UMLS_CUI:C0206663, UMLS_CUI:C1334410
Definition: An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor.

Term Browser
Genes (13)
Models (37)

Disease References using Mouse Models (35)

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Gene: Ifng

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(GFAP-tTA)67Pop/0 \Tg(tetO-Ifng)184Pop/0	B6.Cg-Tg(GFAP-tTA)67Pop Tg(tetO-Ifng)184Pop	J:94092	View
\Tg(GFAP-tTA)67Pop/0 \Tg(tetO-Ifng)184Pop/0	involves: 129S/SvEv * C57BL/6 * DBA/2	J:94092	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Gene: Ptch1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Ptch1tm1Mps/\Ptch1+ \Tg(Atoh1-GFP)1Jejo/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	J:144811	View
\Ptch1tm1Mps/\Ptch1+ \Ptch2tm1Pmc/\Ptch2+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:112118	View
\Ptch1tm1Mps/\Ptch1+ \Ptch2tm1Pmc/\Ptch2tm1Pmc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:112118	View
\Cdkn2ctm1Bbd/\Cdkn2ctm1Bbd \Ptch1tm1Mps/\Ptch1+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	J:102702	View
\Ptch1tm1Zim/\Ptch1+	involves: 129 * CD-1	J:79666	View
\Ptch1tm1Mps/\Ptch1+	involves: 129S1/Sv * 129X1/SvJ	J:144811	View
\Ptch1tm1Bjw/\Ptch1tm1Bjw \Tg(Atoh1-cre/Esr1*)14Fsh/0	involves: 129T2/SvEms * FVB/N	J:139573	View
\Ptch1tm1Mps/\Ptch1+ \Trp53tm1Tyj/\Trp53tm1Tyj	involves: 129 * 129S2/SvPas * C57BL/6	J:67452	View
\Ptch1tm1Bjw/\Ptch1tm1Bjw \Tg(Atoh1-cre)1Bfri/0	involves: 129T2/SvEms * C57BL/6 * CBA	J:139573	View
\Cdkn1btm1Mlf/\Cdkn1btm1Mlf \Ptch1tm1Mps/\Ptch1+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	J:205254	View
\Cdkn1btm1Mlf/\Cdkn1b+ \Ptch1tm1Mps/\Ptch1+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	J:205254	View
\Ptch1tm1Bjw/\Ptch1tm1Bjw \Tg(GFAP-cre)25Mes/0	involves: 129T2/SvEms * FVB/N	J:139573	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Gene: Smo

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Neurod2-SmoA1)199Jols/\Tg(Neurod2-SmoA1)199Jols	C57BL/6-Tg(Neurod2-Smo*A1)199Jols	J:189258	View
\Tg(Neurod2-Smo*A2)#Jols/0	C57BL/6-Tg(Neurod2-Smo*A2)#Jols	J:189258	View
\Tg(Neurod2-Smo*A1)199Jols/0	C57BL/6-Tg(Neurod2-Smo*A1)199Jols	J:93861	View
\Tg(Neurod2-Smo*A1)199Jols/0	involves: C57BL/6	J:221990	View
\Gt(ROSA)26Sortm1(Smo/EYFP)Amc/\Gt(ROSA)26Sortm1(Smo/EYFP)Amc \Olig2tm2(TVA,cre)Rth/\Olig2+	involves: 129 * 129X1/SvJ	J:139574	View
\Gt(ROSA)26Sortm1(Smo/EYFP)Amc/\Gt(ROSA)26Sortm1(Smo/EYFP)Amc \Tlx3tm1(cre)Qima/\Tlx3+	involves: 129X1/SvJ	J:139574	View
\Gt(ROSA)26Sortm1(Smo/EYFP)Amc/\Gt(ROSA)26Sortm1(Smo/EYFP)Amc \Tg(Atoh1-cre/Esr1*)14Fsh/0	involves: 129X1/SvJ * FVB/N	J:139574	View
\Gt(ROSA)26Sortm1(Smo/EYFP)Amc/\Gt(ROSA)26Sortm1(Smo/EYFP)Amc \Tg(GFAP-cre)25Mes/0	involves: 129X1/SvJ * FVB/N	J:139574	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Brca2tm1Brn/\Brca2tm1Brn \Trp53tm1Tyj/\Trp53+ \Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	J:144617	View
\Brca2tm1Brn/\Brca2tm1Brn \Trp53tm1Tyj/\Trp53tm1Tyj \Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	J:144617	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Ptch1tm1Mps/\Ptch1+ \Ptch2tm1Pmc/\Ptch2+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:112118	View
\Ptch1tm1Mps/\Ptch1+ \Ptch2tm1Pmc/\Ptch2tm1Pmc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:112118	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\SufuGt(XB699)Byg/\Sufu+ \Trp53tm1Tyj/\Trp53tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	J:173443	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Transgene: Tg(Neurod2-Smo*A1)199Jols

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Neurod2-SmoA1)199Jols/\Tg(Neurod2-SmoA1)199Jols	C57BL/6-Tg(Neurod2-Smo*A1)199Jols	J:189258	View
\Tg(Neurod2-Smo*A1)199Jols/0	C57BL/6-Tg(Neurod2-Smo*A1)199Jols	J:93861	View
\Tg(Neurod2-Smo*A1)199Jols/0	involves: C57BL/6	J:221990	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Transgene: Tg(Neurod2-Smo*A2)#Jols

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Neurod2-Smo*A2)#Jols/0	C57BL/6-Tg(Neurod2-Smo*A2)#Jols	J:189258	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Transgene: Tg(tetO-Ifng)184Pop

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(GFAP-tTA)67Pop/0 \Tg(tetO-Ifng)184Pop/0	B6.Cg-Tg(GFAP-tTA)67Pop Tg(tetO-Ifng)184Pop	J:94092	View
\Tg(GFAP-tTA)67Pop/0 \Tg(tetO-Ifng)184Pop/0	involves: 129S/SvEv * C57BL/6 * DBA/2	J:94092	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Transgene: Tg(tetO-MYCN,-luc)#Waw

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Slc1a2-tTA)#Waw/0 \Tg(tetO-MYCN,-luc)#Waw/0	involves: FVB/NJ	J:160518	View
\Tg(Slc1a2-tTA)#Waw/0 \Tg(tetO-MYCN,-luc)#Waw/\Tg(tetO-MYCN,-luc)#Waw	involves: FVB/NJ	J:160518	View

Mouse Models

Human Disease Modeled: medulloblastoma
Associated Mouse Transgene: Tg(tetO-TAg,CMV-rtTA)123Yihu

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(tetO-TAg,CMV-rtTA)123Yihu/0	involves: FVB/N	J:141623	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Rag1tm1Mom/\Rag1tm1Mom \Trp53tm1Brd/\Trp53tm1Brd \Xrcc5tm1Dbr/\Xrcc5tm1Dbr	involves: 129S7/SvEvBrd * C57BL	J:141515	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Rb1tm2Brn/\Rb1tm2Brn \Trp53tm1Brd/\Trp53tm1Brd \Tg(Gfap-cre)2Brn/0	involves: 129 * 129S7/SvEvBrd * FVB/N	J:61961	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Rb1tm2Brn/\Rb1tm2Brn \Trp53tm1Brn/\Trp53tm1Brn \Tg(Gfap-cre)2Brn/0	involves: 129P2/OlaHsd * FVB/N	J:61961	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Trp53tm1Brd/\Trp53tm1Brd \Xrcc4tm2.1Fwa/\Xrcc4tm2Fwa \Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL	J:109585	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Lig4tm1Icrf/\Lig4tm1Icrf \Trp53tm1Tyj/\Trp53tm1Tyj	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	J:173443	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Cdkn2ctm1Bbd/\Cdkn2c+ \Trp53tm1Tyj/\Trp53tm1Tyj	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	J:102702	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Cdkn2ctm1Bbd/\Cdkn2ctm1Bbd \Trp53tm1Tyj/\Trp53tm1Tyj	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	J:102702	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Cdkn2ctm1Bbd/\Cdkn2ctm1Bbd \Trp53tm1Brn/\Trp53tm1Tyj \Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	J:102702	View

Mouse Models

Human Disease Modeled: medulloblastoma

Allelic Composition	Genetic Background	Reference	Phenotypes
\Ptentm2Mak/\Ptentm2Mak \Trp53tm1Brn/\Trp53tm1Brn \Tg(Nes-cre/ERT2,-ALPP)1Sbk/0	involves: 129P2/OlaHsd	J:237990	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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