Phenotypes Associated with This Genotype

Genotype
MGI:5286072

• Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129T2/SvEms * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:139573 )

• by 4 weeks, mice become severely ill and must be sacrificed

nervous system

increased medulloblastoma incidence ( J:139573 )

abnormal cerebellum external granule cell layer morphology ( J:139573 )

• expanded at E16.5

• thick and disorganized, at birth

abnormal rhombic lip morphology ( J:139573 )

• rhombic lip expansion at E16.5

increased neuronal precursor cell number ( J:139573 )

• cerebellar cells exhibit increased neurospheres compared with wild-type mice

neoplasm

increased medulloblastoma incidence ( J:139573 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:139573