Phenotypes Associated with This Genotype

Genotype
MGI:5570748

• Allelic Composition: Tg(Slc1a2-tTA)#Waw/0; Tg(tetO-MYCN,-luc)#Waw/Tg(tetO-MYCN,-luc)#Waw
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:160518 )

• survival is 50% at 100 days and 25% after 200 days

neoplasm

increased metastatic potential ( J:160518 )

• a few mutants show disseminated tumor in the lumbrosacral region, partially encasing nerve roots in the subarachnoid spaces adjacent to the spinal cord, indicating spinal metastases

increased malignant tumor incidence ( J:160518 )

• spinal metastases are discontinuous with primary tumors, suggesting leptomeningeal spread through cerebrospinal fluid

increased medulloblastoma incidence ( J:160518 )

• mice develop aggressive medulloblastoma of either classical or large cell anaplastic pathology with high penetrance

nervous system

increased medulloblastoma incidence ( J:160518 )

• mice develop aggressive medulloblastoma of either classical or large cell anaplastic pathology with high penetrance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:160518