Brca2^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Brn
• Name: breast cancer 2, early onset; targeted mutation 1, Anton Berns
• MGI ID: MGI:2156556
• Synonyms: Brca2^F11, Brca2^F11F, Brca2^LoxP
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Brn page

Prostate hyperplasia and low-grade prostate intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73028
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 11 by homologous recombination. Subsequent Cre-mediated recombination in ES cells excised an adjacent PGK-neomycin and thymidine kinase cassette prior to the production of chimeric mice. (J:73028)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
• All: 43 reference(s)