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Transgene Detail
Symbol: Tg(Nes-cre)1Kln
Name: transgene insertion 1, Rudiger Klein
MGI ID: MGI:2176173
Synonyms: n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
Transgene: Tg(Nes-cre)1Kln  Location: Chr12:90491366-90491383 bp  Genetic Position: Chr12, Syntenic
Alliance: Tg(Nes-cre)1Kln page
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Recombinase)
Mutations:    Insertion, Intergenic deletion
Tg(Nes-cre)1Kln expression driven by 1 gene
Mutation detailsThis transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion. (J:57315, J:133340, J:164338, J:180046)
 Tissue activity of this recombinase allele
Driver: Nes (rat)
Summary of all recombinase alleles driven by Nes.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1410 assay results
66 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Nes-cre)1Kln
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
Original:  J:57315 Tronche F, et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999 Sep;23(1):99-103
All:  1347 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory