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Targeted Allele Detail
Symbol: Ptch1tm1Mps
Name: patched 1; targeted mutation 1, Matthew P Scott
MGI ID: MGI:1857447
Synonyms: LacZ/Ptc, ptc-, Ptc1-, Ptc1-lacZ, Ptc1lzki, Ptch-, Ptch1-, Ptch1-lacZ, PtchKO1, PtchlacZ, ptc-lacZ, PtclacZ, Ptcn
Gene: Ptch1  Location: Chr13:63656142-63721274 bp, - strand  Genetic Position: Chr13, 32.8 cM
Alliance: Ptch1tm1Mps page
Skeletal abnormalities in Ptch1dl/Ptch1tm1Mps mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:42441
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice. (J:42441)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 337 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 19 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ptch1tm1Mps
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:  91 strains or lines available
Original:  J:42441 Goodrich LV, et al., Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22;277(5329):1109-13
All:  322 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory