Phenotypes Associated with This Genotype

Genotype
MGI:3759457

• Allelic Composition: Sufu^Gt(XB699)Byg/Sufu⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125534 )

• mice die around 4 months of age compared to Trp53^tm1Tyj homozygotes that survive to 5 months

neoplasm

increased rhabdomyosarcoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

increased lymphoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53^tm1Tyj

increased medulloblastoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

nervous system

increased medulloblastoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle

increased rhabdomyosarcoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:173443