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Targeted Allele Detail
Symbol: Ptentm2Mak
Name: phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
MGI ID: MGI:2182005
Synonyms: PTENCo, Ptenf, Ptenfl, Ptenflox, PtenL, PtenloxP
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm2Mak page
Urothelial hyperplasia and increased apoptosis in bladder epithelium of Ptentm2Mak/Ptentm2Mak Stk11tm1Keis/Stk11tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69471
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsOne loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele. (J:69471)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 49 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Ptentm2Mak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  76 strains or lines available
Original:  J:69471 Suzuki A, et al., T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity. 2001 May;14(5):523-34
All:  239 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory