Phenotypes for Brca2 Tg(Nes-cre)1Kln Trp53 MGI:3831340 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Brca2^tm1Brn/Brca2^tm1Brn Trp53^tm1Tyj/Trp53⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:144617 )

• tumors exhibit a loss of heterozygosity at the Trp53 gene

increased medulloblastoma incidence ( J:144617 )

• 72% of mice develop medulloblastoma beginning at 21 weeks

nervous system

increased medulloblastoma incidence ( J:144617 )

• 72% of mice develop medulloblastoma beginning at 21 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:144617

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23