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Targeted Allele Detail
Symbol: Rb1tm2Brn
Name: RB transcriptional corepressor 1; targeted mutation 2, Anton Berns
MGI ID: MGI:1931018
Synonyms: flox19-RB1, pRbL2, pRblox, Rbf, RbF19, Rblox, RbLoxP
Gene: Rb1  Location: Chr14:73430298-73563446 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Alliance: Rb1tm2Brn page
Germline Transmission:  Earliest citation of germline transmission: J:61961
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis. (J:61961)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 12 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Rb1tm2Brn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  107 strains or lines available
Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.

Phenotypic Similarity to Human Syndrome: Glucagonoma J:216559 in double homozygous Rb1 and Trp53 conditional mutants.

Original:  J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
All:  211 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory