Phenotypes Associated with This Genotype

Genotype
MGI:3819453

• Allelic Composition: Tg(tetO-TAg,CMV-rtTA)123Yihu/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141623 )

• after two months of induction with doxycycline, 22 of 24 mice are moribund with medulloblastoma

neoplasm

increased medulloblastoma incidence ( J:141623 )

• 22 of 24 doxycycline-induced mice develop medulloblastoma

• however, few un-induced mice develop brain tumors after 12 months of age

craniofacial

abnormal cranium morphology ( J:141623 )

• at 2 months doxycycline-induced mice exhibit ridgy craniums unlike in wild-type mice

skeleton

abnormal cranium morphology ( J:141623 )

• at 2 months doxycycline-induced mice exhibit ridgy craniums unlike in wild-type mice

nervous system

increased medulloblastoma incidence ( J:141623 )

• 22 of 24 doxycycline-induced mice develop medulloblastoma

• however, few un-induced mice develop brain tumors after 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:141623