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Phenotypes Associated with This Genotype
Genotype
MGI:3655296
Allelic
Composition		 Lig4tm1Icrf/Lig4tm1Icrf
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Icrf mutation (0 available); any Lig4 mutation (46 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:111068 )
• pro-B cell lymphomas develop by 12 weeks of age
increased medulloblastoma incidence ( J:111068 )
• mice develop tumors by 12 weeks of age

nervous system
increased medulloblastoma incidence ( J:111068 )
• mice develop tumors by 12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:173443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory