Cdkn2c^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Cdkn2c^tm1Bbd
• Name: cyclin dependent kinase inhibitor 2C; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1933761
• Synonyms: Ink4c-, p18^INK4c-
• Gene: Cdkn2c Location: Chr4:109518073-109523953 bp, - strand Genetic Position: Chr4, 51.32 cM
• Alliance: Cdkn2c^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63299
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding amino acid residues 43-168, was replaced by a neomycin cassette. No protein was detected in Western blots of lysates derived from tissues of 3 month old homozygous mutant mice. (J:63299)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2c^tm1Bbd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn2c Mutation: 16 strains or lines available

References

• Original: J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
• All: 28 reference(s)