multiple sclerosis Disease Ontology Browser

Disease Ontology Browser

multiple sclerosis (DOID:2377)
Alliance: disease page
Synonyms: Generalized multiple sclerosis; insular sclerosis
Alt IDs: OMIM:612594, OMIM:612595, OMIM:612596, ICD10CM:G35, ICD9CM:340, MESH:D009103, NCI:C3243, UMLS_CUI:C0026769
Definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Term Browser
Genes (81)
Models (22)

Disease References using Mouse Models (24)

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Gene: Prf1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Prf1tm1Sdz/\Prf1tm1Sdz	C57BL/6-Prf1^tm1Sdz/J	J:120427	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Gene: Tnf

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Tnf)6074Gkl/0	involves: C57BL/6 * CBA	J:106592	View
\Tg(Tnf)6074Gkl/0 \Tnfrsf1btm1Mwm/\Tnfrsf1btm1Mwm	involves: 129S2/SvPas * C57BL/6 * CBA	J:106592	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Gene: Lrch1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Lrch1em1Hwa/\Lrch1em1Hwa	Not Specified	J:238772	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2dlAb1-Ea/\H2dlAb1-Ea \Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 \Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	J:189816	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2dlAb1-Ea/\H2dlAb1-Ea \Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 \Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	J:189816	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2dlAb1-Ea/\H2dlAb1-Ea \Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 \Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	J:189816	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2dlAb1-Ea/\H2dlAb1-Ea \Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 \Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	J:189816	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Mogtm1(cre)Gkl/\Mogtm1(cre)Gkl \Tg(Tcra2D2,Tcrb2D2)1Kuch/0	C57BL/6-Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch	J:151335	View
\Igh-Jtm1Aigl/\Igh-J+ \Mogtm1Dpd/\Mogtm1Dpd \Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	J:151335	View
\Mogtm1Dpd/\Mogtm1Dpd \Rag2tm1Cgn/\Rag2tm1Cgn \Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S2/SvPas * C57BL/6	J:151335	View
\Mogtm1Dpd/\Mogtm1Dpd \Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S2/SvPas * C57BL/6	J:151335	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Gfap-TNF*)K21Gkl/0 \Tnfrsf1atm1Blt/\Tnfrsf1a+	involves: 129P2/OlaHsd * C57BL/6 * CBA	J:106592	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Transgene: Tg(Gfap-TNF*)K21Gkl

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Gfap-TNF*)K21Gkl/0	involves: C57BL/6 * CBA	J:106592	View
\Tg(Gfap-TNF*)K21Gkl/0 \Tnfrsf1atm1Blt/\Tnfrsf1a+	involves: 129P2/OlaHsd * C57BL/6 * CBA	J:106592	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Transgene: Tg(H2-K^b-Tcra,-Tcrb)1640Kurs

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0	SJL.FVB-Tg(H2-K^b-Tcra,-Tcrb)1640Kurs	J:149511	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Transgene: Tg(Mbp-Pad2)28Fgm

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Mbp-Pad2)28Fgm/\Tg(Mbp-Pad2)28Fgm	involves: CD-1	J:142650	View
\Tg(Mbp-Pad2)28Fgm/0	involves: CD-1	J:142650	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Transgene: Tg(PLP1*)4Rsj

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(PLP1*)4Rsj/0	involves: CD-1	J:161344, J:171534	View

Mouse Models

Human Disease Modeled: multiple sclerosis
Associated Mouse Transgene: Tg(Tnf)6074Gkl

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Tnf)6074Gkl/0	involves: C57BL/6 * CBA	J:106592	View
\Tg(Tnf)6074Gkl/0 \Tnfrsf1btm1Mwm/\Tnfrsf1btm1Mwm	involves: 129S2/SvPas * C57BL/6 * CBA	J:106592	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2u/\H2u \Tg(TCRA)B1Jg/? \Tg(TCRB)C14Jg/?	involves: C57BL/6 * C57BL/10SnSg * DBA/2 * PL/J	J:92991	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\H2u/\H2u \Rag1tm1Mom/\Rag1tm1Mom \Tg(Tcra19,Tcrb19)#Stl/0	either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)	J:19795	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Igh-Jtm1Aigl/\Igh-J+ \Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	J:151335	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Rag2tm1.1Cgn/\Rag2tm1.1Cgn \Tg(HLA-DR2)#Lfug/0 \Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2	J:134764	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Gt(ROSA)26Sortm1(DTA)Jpmb/\Gt(ROSA)26Sor+ \Tg(Plp1-cre/ERT)3Pop/0	involves: 129S/SvEv * C57BL/6 * DBA/2	J:234435	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Cd4-CD4)2362Litt/0 \Tg(HLA-DR2)#Lfug/0 \Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2 * SJL	J:134764	View

Mouse Models

Human Disease Modeled: multiple sclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(HLA-DR2)#Lfug/0 \Tg(TCROb.1A12)#Lfug/0	involves: C57BL/6 * DBA/2	J:134764	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24