Tg(TRATL3A6,TRBTL3A6)#Kito
Transgene Detail

Summary

• Symbol: Tg(TRATL3A6,TRBTL3A6)#Kito
• Name: transgene insertion, Kouichi Ito
• MGI ID: MGI:5635436
• Synonyms: TL3A6
• Transgene: Tg(TRATL3A6,TRBTL3A6)#Kito Location: unknown
• Alliance: Tg(TRATL3A6,TRBTL3A6)#Kito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TRATL3A6,TRBTL3A6)#Kito expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TRA (6955)

  Trac	(MGI:4439838)

  human

  TRB (6957)

  Trbc1	(MGI:4439726)
  Trbc2	(MGI:4835227)

• Mutation details: This transgene expresses a Multiple Sclerosis patient-derived HLA DRB5*01:01-restricted myelin basic protein (83-99) specific TCR (TCR alpha and beta chains of the TL3A6 TCR). TL3A6 expresses Valpha9.2-Jalpha12-Calpha and Vbeta5.1-D-Jbeta1.2-Cbeta. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:189816)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189816 Quandt JA, et al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol. 2012 Sep 15;189(6):2897-908
• All: 2 reference(s)