Trac Gene Detail

Summary

• Symbol
  Trac
• Name
  T cell receptor alpha constant
• Synonyms
  Gm16914

• Feature Type
  gene segment
• IDs
  MGI:4439838
  NCBI Gene: 100101484
• Alliance
  genome feature page
• Transcription Start Sites
  11 TSS

Location &
Maps

• Sequence Map
  Chr14:54457978-54461655 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 27.70 cM
• Mapping Data
  14 experiments

Strain
Comparison

• SNPs within 2kb
  97 from dbSNP Build 142
• Strain Annotations
  19
• RFLP
  5

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439838	gene segment	Chr14:54457978-54461663 (+)
129S1/SvImJ	ENSMUSG00200044831	gene segment	Chr14:43050288-43053964 (+)
A/J	ENSMUSG00195036232	gene segment	Chr14:43274568-43278245 (+)
AKR/J	ENSMUSG00220032102	gene segment	Chr14:42602507-42606185 (+)
BALB/cJ	ENSMUSG00180052226	gene segment	Chr14:42898330-42902006 (+)
C3H/HeJ	ENSMUSG00175051844	gene segment	Chr14:44580767-44584444 (+)
C57BL/6NJ	ENSMUSG00215048960	gene segment	Chr14:42780282-42783967 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002120	gene segment	Chr14:45653430-45657119 (+)
CAST/EiJ	ENSTCUG00005050845	gene segment	Chr14:44576927-44580589 (+)
CBA/J	ENSMUSG00210048259	gene segment	Chr14:43261333-43265009 (+)
DBA/2J	ENSMUSG00185054862	gene segment	Chr14:48302021-48305699 (+)
FVB/NJ	ENSMUSG00205046859	gene segment	Chr14:42644271-42647948 (+)
JF1/MsJ	ENSUMUG00000053603	gene segment	Chr14:59560480-59564166 (+)
LP/J	ENSMUSG00230053147	gene segment	Chr14:60416279-60419955 (+)
NOD/ShiLtJ	ENSMUSG00190050499	gene segment	Chr14:43005086-43008762 (+)
NZO/HlLtJ	ENSMUSG00225051408	gene segment	Chr14:50714371-50718047 (+)
PWK/PhJ	ENSLUMG00010051621	gene segment	Chr14:42484392-42488068 (+)
SPRET/EiJ	ENSMSPG00010049260	gene segment	Chr14:45874910-45878594 (+)
WSB/EiJ	ENSIUOG00005044799	gene segment	Chr14:42476085-42479761 (+)

Homology

• Human Ortholog
  TRA, T cell receptor alpha locus

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRA, T cell receptor alpha locus
  
• Synonyms
  IMD7, TCRA, TRA@
• Links
  HGNC:12027

  NCBI Gene ID: 6955

  UniProt: P0DSE1, P0DTU3

  
  
• Chr Location
  14q11.2; chr14:21621904-22552132 (+)  GRCh38

---

• Human Ortholog
  TRAC, T cell receptor alpha constant
  
• Synonyms
  IMD7, TCRA, TRCA
• Links
  HGNC:12029

  NCBI Gene ID: 28755

  UniProt: P01848

  
  
• Chr Location
  14q11.2; chr14:22547506-22552156 (+)  GRCh38

---

• MGI Vertebrate Homology
  Trac stringent orthology
  2 human;1 mouse
  
• HCOP
  vertebrate homology predictions: TRA, TRAC
• Gene Tree
  Trac
  

Human Diseases

• Diseases
  1 with human TRAC associations

				Human Disease	Mouse Models
				immunodeficiency 7 IDs immunodeficiency 7       DOID:0111977 OMIM:615387 ORDO:397959 UMLS_CUI:C3809332 UMLS_CUI:C5190592

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotype references
  

• All Mutations and Alleles
  17
• Endonuclease-mediated
  8
• Gene trapped
  2
• Targeted
  3
• Transgenic
  3
• Genomic Mutations
  3 involving Trac
• Incidental Mutations
  APF
• Find Mice (IMSR)
  9 strains or lines available

Expression

• Assay Results
  650
• Tissues
  46
• cDNA Data
  5
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase trac

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000076928 (Evidence)
• NCBI Gene
  100101484

Representative Sequences			Length	Strain/Species
genomic	100101484	NCBI Gene Model | MGI Sequence Detail	3678	C57BL/6J
polypeptide	A0A991BQX6	UniProt | EBI | MGI Sequence Detail	137	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR015370 T-cell receptor alpha chain, constant domain

Molecular
Reagents

• All nucleic 93

  Genomic 27

  cDNA 61

  Primer pair 1

  Other 4

Other
Accession IDs

MGD-MRK-14846, MGI:98554

References

• Summaries
  All 63

  Developmental Gene Expression 3

  Phenotypes 13
• Earliest
  J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
• Latest
  J:389261 Tsai AK, et al., Maturation of thymocytes with a monoclonal TCR under control of Trac promoter elements in the absence of beta-selection. Immunohorizons. 2025 Jul 15;9(8)

TSS for Trac:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125597	Chr14:54456431-54456442 (+)	-1,541 bp
Tssr125598	Chr14:54456487-54456496 (+)	-1,486 bp
Tssr125599	Chr14:54458023-54458042 (+)	55 bp
Tssr125600	Chr14:54458153-54458167 (+)	182 bp
Tssr125601	Chr14:54459694-54459713 (+)	1,726 bp
Tssr125602	Chr14:54459821-54459831 (+)	1,848 bp
Tssr125603	Chr14:54460195-54460211 (+)	2,225 bp
Tssr125604	Chr14:54460231-54460246 (+)	2,261 bp
Tssr125605	Chr14:54460265-54460276 (+)	2,293 bp
Tssr125606	Chr14:54460295-54460307 (+)	2,323 bp
Tssr125607	Chr14:54461172-54461190 (+)	3,203 bp