Tg(Mbp-Pad2)28Fgm
Transgene Detail
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Symbol: |
Tg(Mbp-Pad2)28Fgm |
Name: |
transgene insertion 28, Fabrizio G Mastronardi |
MGI ID: |
MGI:4459094 |
Synonyms: |
PD2 |
Transgene: |
Tg(Mbp-Pad2)28Fgm Location: unknown
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Alliance: |
Tg(Mbp-Pad2)28Fgm page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Mbp-Pad2)28Fgm expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Padi2 (29511) |
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Mutation details: A 1.9 kb fragment of the mouse Mbp promoter (from the pMG2 plasmid) drives expression of a 2.3 kb cDNA fragment encoding rat Pad2. This line contains 15 copies of the transgene. Immunohistochemical analysis indicates increased expression in the white matter tracts of the corpus callosum. Immunoslot blot analysis of whole brain homogenates also indicates increased expression in mice at 2 to 6 months of age. Myelin samples from the central nervous system contain increased levels of MBP citrullination.
(J:142650)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:142650 Musse AA, et al., Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech. 2008 Nov;1(4-5):229-40 |
All: |
2 reference(s) |
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