Phenotypes Associated with This Genotype

Genotype
MGI:4459096

• Allelic Composition: Tg(Mbp-Pad2)28Fgm/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

convulsive seizures ( J:142650 )

• develop convulsions by 1.5 months of age

astrocytosis ( J:142650 )

• in the cerebellum and C1-C5 regions of the spinal cord at 6 months of age

abnormal myelin sheath morphology ( J:142650 )

• optic nerves display areas of myelinolysis and thinly myelinated axons

• gene dosage correlated decrease in myelinated fiber density and myelin thickness

demyelination ( J:142650 )

• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age

• signs increase in severity with age but not as rapidly as in homozygous mice

behavior/neurological

tremors ( J:142650 )

• develop tremors by 1.5 months of age

abnormal motor coordination/balance ( J:142650 )

• display proprioceptive positioning defects at 4 months of age

impaired righting response ( J:142650 )

• becomes impaired by 1.5 months of age

impaired balance ( J:142650 )

• at 4 months of age

impaired coordination ( J:142650 )

• at 4 months of age

abnormal posture ( J:142650 )

• develop tail droop by 1.5 months of age

head shaking ( J:142650 )

• develops by 1.5 months of age

abnormal gait ( J:142650 )

• develop a shaky gait by 1.5 months of age

convulsive seizures ( J:142650 )

• develop convulsions by 1.5 months of age

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:142650 )

• increase in the levels in the brain by 4 months of age

immune system

abnormal tumor necrosis factor level ( J:142650 )

• increase in the levels in the brain by 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:142650