Tg(Plp1-cre/ERT)3Pop
Transgene Detail

Summary

• Symbol: Tg(Plp1-cre/ERT)3Pop
• Name: transgene insertion 3, Brian Popko
• MGI ID: MGI:2450391
• Synonyms: PLP/CreER, Plp-CreER^t, Plp-Cre-ER^T2, Tg(Plp1-cre/ESR1)3.16Pop, Tg(Plp1-cre/ESR1)3Pop, Tg(Plp-cre/ESR1)3.16Pop
• Transgene: Tg(Plp1-cre/ERT)3Pop Location: unknown
• Alliance: Tg(Plp1-cre/ERT)3Pop page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Plp1-cre/ERT)3Pop expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Plp1

• Mutation details: The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain cloned next to a Plp promoter. The 2.5 kb Plp regulatory region includes 5' flanking DNA, exon 1, and intron 1. Transgene expression was confirmed by RT-PCR and Western blot analysis. The mouse Plp promoter was used to drive transgene expression in myelinating cells. (J:81627)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Plp1 (species not specified) Summary of all recombinase alleles driven by Plp1. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:81627 Doerflinger NH, et al., Inducible site-specific recombination in myelinating cells. Genesis. 2003 Jan;35(1):63-72
• All: 147 reference(s)