Phenotypes Associated with This Genotype

Genotype
MGI:5429704

• Allelic Composition: Tg(Cd4-CD4)2362Litt/0; Tg(HLA-DR2)#Lfug/0; Tg(TCROb.1A12)#Lfug/0
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:134764 )

• some mice die due to advanced disease during the onset of disease following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin 85-90% of mice develop disease

• onset, clinical manifestations and course of disease are highly variable

• some mice die due to advanced disease during the onset of disease others develop a relapsing-remitting disease after the first attack

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:134764 )

• following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin mice show one or more behavioral abnormalities indicative of white matter defects

lethargy ( J:134764 )

• drowsy

impaired balance ( J:134764 )

impaired coordination ( J:134764 )

abnormal locomotor activation ( J:134764 )

• slow movement

abnormal locomotor coordination ( J:134764 )

• spasticity

abnormal gait ( J:134764 )

• staggering gait

forelimb paralysis ( J:134764 )

nervous system

CNS inflammation ( J:134764 )

• spinal inflammation following immunization with MBP 84-102 peptide in complete Freund's adjuvant and pertussis toxin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764