Igh-J^tm1Aigl
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Aigl
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Antonio Iglesias
• MGI ID: MGI:3665428
• Synonyms: IgH^MOG, Th
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Ig deposition and B cell infiltrates in spinal cord of sick Tg(H2-K^b-Tcra,-Tcrb)1640Kurs/0 Igh-J^tm1Aigl/Igh-J^tm1Aigl and Tg(H2-K^b-Tcra,-Tcrb)1640Kurs/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111543
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• A rearranged VHDJH gene with a neo cassette replaced the DQ52/JH1-4 region. (J:111543)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:111543 Litzenburger T, et al., B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med. 1998 Jul 6;188(1):169-80
• All: 22 reference(s)