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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifng
interferon gamma
MGI:107656
121 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Ifngtm1Ts/Ifngtm1Ts
B6.129-Apoetm1Unc Ifngtm1Ts 		dilated aorta J:166204
increased body weight J:166204
increased susceptibility to induced aneurysm formation J:166204
increased susceptibility to induced morbidity/mortality J:166204
Casp3tm1Flv/Casp3tm1Flv
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal lung volume J:100854
emphysema J:100854
increased apoptosis J:100854
increased lung compliance J:100854
increased lymphocyte cell number J:100854
increased macrophage cell number J:100854
increased neutrophil cell number J:100854
Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		increased B cell derived lymphoma incidence J:83086
increased carcinoma incidence J:83086
increased eosinophil cell number J:83086
increased IgE level J:83086
increased IgG1 level J:83086
increased immunoglobulin level J:83086
increased inflammatory response J:83086
increased ovarian carcinoma incidence J:83086
postnatal lethality, incomplete penetrance J:83086
premature death J:83086
Csf2tm1Mlg/Csf2tm1Mlg
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
B6.129S-Csf2tm1Mlg Il3tm1Glli Ifngtm1TsIfngtm1Ts 		normal homeostasis/metabolism phenotype J:145518
increased pituitary adenoma incidence J:145518
Ctsstm1Hap/Ctsstm1Hap
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal lung volume J:100854
emphysema J:100854
increased apoptosis J:100854
increased lung compliance J:100854
increased lymphocyte cell number J:100854
increased macrophage cell number J:100854
increased neutrophil cell number J:100854
Eif2ak3tm1Dron/Eif2ak3+
Tg(GFAP-tTA)110Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster 		abnormal myelination J:99655
abnormal oligodendrocyte apoptosis J:99655
abnormal oligodendrocyte morphology J:99655
abnormal spinal cord white matter morphology J:99655
increased spinal cord apoptosis J:99655
postnatal growth retardation J:99655
premature death J:99655
tonic seizures J:99655
tremors J:99655
Eif2ak3tm1Dron/Eif2ak3tm1Dron
Tg(GFAP-tTA)110Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster 		postnatal lethality, complete penetrance J:99655
Faslpr/Faslpr
Ifngtm1Ts/Ifng+
MRL.Cg-Ifngtm1Ts Faslpr 		abnormal glomerular capillary morphology J:123834
abnormal macrophage chemotaxis J:123834
abnormal renal glomerulus morphology J:123834
glomerulonephritis J:123834
increased autoantibody level J:123834
increased blood urea nitrogen level J:123834
increased mesangial cell number J:123834
premature death J:123834
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp 		abnormal lymph node size J:39600
abnormal spleen size J:39600
decreased anti-double stranded DNA antibody level J:39600
decreased anti-nuclear antigen antibody level J:39600
decreased autoantibody level J:39600
decreased circulating creatinine level J:39600
decreased double-negative T cell number J:39600
decreased IgA level J:39600
decreased IgG2a level J:39600
decreased IgG2b level J:39600
decreased IgM level J:39600
decreased immunoglobulin level J:39600
decreased susceptibility to systemic lupus erythematosus J:39600
enlarged lymph nodes J:39600
enlarged spleen J:39600
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
MRL.Cg-Ifngtm1Ts Faslpr 		abnormal macrophage chemotaxis J:123834
abnormal renal glomerulus morphology J:123834
normal immune system phenotype J:123834
kidney inflammation J:123834
lung inflammation J:123834
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ 		normal immune system phenotype J:189962
increased CD4-positive, alpha-beta T cell number J:189962
increased CD8-positive, alpha-beta T cell number J:189962
normal mortality/aging J:189962
Ifngtm1(Thy1)Weav/?
involves: C57BL/6 		no abnormal phenotype detected J:144542
Ifngtm1Ts/Ifng+
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		decreased survivor rate J:57474
premature death J:57474
Ifngtm1Ts/Ifngtm1Ts
Ldlrtm1Her/Ldlrtm1Her
B6.129S7-Ldlrtm1Her Ifngtm1Ts 		atherosclerotic lesions J:103072
increased T cell number J:103072
Ifngtm1Ts/Ifngtm1Ts
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S7/SvEvBrd * C57BL/6 		brain inflammation J:191055
normal immune system phenotype J:191055
Ifngtm1Ts/Ifngtm1Ts
Pld4tm1.2Nemz/Pld4tm1.2Nemz
involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N 		decreased NK T cell number J:281205
normal hematopoietic system phenotype J:281205
increased susceptibility to induced morbidity/mortality J:281205
Ifngtm1Ts/Ifngtm1Ts
Prf1tm1Sdz/Prf1tm1Sdz
C.Cg-Prf1tm1Sdz Ifngtm1Ts 		abnormal tumor morphology J:77491
decreased tumor latency J:77491
increased B cell derived lymphoma incidence J:77491
increased lymphoma incidence J:77491
premature death J:77491
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Jni/Socs1tm1Jni
involves: 129S7/SvEvBrd 		increased interleukin-17 secretion J:132905
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal lactation J:70408
abnormal lung vasculature morphology J:57474
abnormal mammary gland growth during pregnancy J:70408
enlarged thymus medulla J:57474
normal hematopoietic system phenotype J:57474
mammary gland alveolar hyperplasia J:70408
normal mortality/aging J:57474, J:70408
Ifngtm1Ts/Ifngtm1Ts
Tg(SFTPC-Il18)AThos/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2 		abnormal lung volume J:147547
abnormal pulmonary alveolus morphology J:147547
emphysema J:147547
lung inflammation J:147547
Ifngtm1Ts/Ifngtm1Ts
Tgfb1tm1Doe/Tgfb1tm1Doe
C.129-Ifngtm1Ts Tgfb1tm1Doe 		cachexia J:69346
decreased body weight J:69346
increased circulating alanine transaminase level J:69346
liver inflammation J:69346
normal liver/biliary system phenotype J:69346
premature death J:69346
Ifngtm1Ts/Ifngtm1Ts
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL 		normal immune system phenotype J:196160
normal mortality/aging J:196160
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J 		small intestinal inflammation J:108572
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
increased eosinophil cell number J:119206
increased leukocyte cell number J:119206
increased lymphocyte cell number J:119206
increased susceptibility to fungal infection J:119206
lung inflammation J:119206
small Peyer's patches J:119206
Stat1tm1Rds/Stat1tm1Rds
Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S/SvEv * C57BL/6 * DBA/2 		ataxia J:94092
normal mortality/aging J:94092
normal neoplasm J:94092
prenatal lethality, complete penetrance J:94092
tremors J:94092
Tg(APCS-Ifng)5Imeg/0
involves: C57BL/6 * DBA/2 		abnormal circulating enzyme level J:16979
abnormal cytokine level J:135124
abnormal heart echocardiography feature J:135124
abnormal heart morphology J:135124
abnormal liver morphology J:16979
abnormal myocardial fiber morphology J:135124
cardiac interstitial fibrosis J:135124
cardiac muscle atrophy J:135124
cardiac muscle degeneration J:135124
chronic liver inflammation J:135124
decreased cardiac muscle contractility J:135124
dilated cardiomyopathy J:135124
dilated heart left ventricle J:135124
increased circulating alanine transaminase level J:135124
increased circulating interleukin-12 level J:135124
liver fibrosis J:16979
liver inflammation J:16979
liver vascular congestion J:135124
myocarditis J:135124
pancreas inflammation J:135124
premature death J:16979
Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
B6.Cg-Tg(GFAP-tTA)67Pop Tg(tetO-Ifng)184Pop 		abnormal cerebellum external granule cell layer morphology J:94092
abnormal cerebellum morphology J:94092
ataxia J:94092
increased medulloblastoma incidence J:94092
normal mortality/aging J:94092
neonatal lethality, incomplete penetrance J:94092
postnatal growth retardation J:94092
postnatal lethality, complete penetrance J:94092
tremors J:94092
Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S/SvEv * C57BL/6 * DBA/2 		increased medulloblastoma incidence J:94092
Tg(GFAP-tTA)78Pop/0
Tg(tetO-Ifng)184Pop/0
B6.Cg-Tg(GFAP-tTA)78Pop Tg(tetO-Ifng)184Pop 		abnormal cerebellum development J:109838
abnormal cerebellum external granule cell layer morphology J:109838
abnormal interferon-gamma secretion J:109838
ataxia J:109838
CNS inflammation J:109838
decreased body size J:109838
enlarged cerebellum J:109838
Tg(GFAP-tTA)110Pop/0
Tg(tetO-Ifng)184Pop/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster 		ataxia J:99655
normal mortality/aging J:99655
tremors J:99655
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0
involves: C57BL/6 * CBA 		abnormal lung volume J:100854
emphysema J:100854
increased apoptosis J:100854
increased lung compliance J:100854
increased lymphocyte cell number J:100854
increased macrophage cell number J:100854
increased neutrophil cell number J:100854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory