Ldlrtm1Her
Targeted Allele Detail
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Symbol: |
Ldlrtm1Her |
Name: |
low density lipoprotein receptor; targeted mutation 1, Joachim Herz |
MGI ID: |
MGI:1857212 |
Synonyms: |
LDLR-, LDLr0, LDLrKO, LDLr-KO, LDLR KO, Ldlrtm1Her |
Gene: |
Ldlr Location: Chr9:21634872-21661215 bp, + strand Genetic Position: Chr9, 7.87 cM
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Alliance: |
Ldlrtm1Her page
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Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her mice
Show the 9 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:37394
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
(J:37394)
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View phenotypes and curated references for all genotypes (concatenated display).
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When used in bone marrow transplant into Ldlr tm1Her homozygous mice, Abca1 tm1Jdm Abcg1 tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
Phenotypic Similarity to Human Syndrome: Atherosclerosis, Susceptibility to J:29950, J:225091 in mice fed a high-cholesterol diet.
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Original: |
J:37394 Ishibashi S, et al., Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]. J Clin Invest. 1993 Aug;92(2):883-93 |
All: |
1356 reference(s) |
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