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Targeted Allele Detail
Symbol: Tgfb1tm1Doe
Name: transforming growth factor, beta 1; targeted mutation 1, Thomas Doetschman
MGI ID: MGI:1857258
Synonyms: Tgfb1-, TGFbeta1
Gene: Tgfb1  Location: Chr7:25386427-25404502 bp, + strand  Genetic Position: Chr7, 13.98 cM
Alliance: Tgfb1tm1Doe page
Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:2892
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 6 of the gene, disrupting the production of a mature peptide. (J:2892)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tgfb1tm1Doe
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:  27 strains or lines available
Original:  J:2892 Shull MM, et al., Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992 Oct 22;359(6397):693-9
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory