Pld4^tm1.2Nemz
Targeted Allele Detail

Summary

• Symbol: Pld4^tm1.2Nemz
• Name: phospholipase D family member 4; targeted mutation 1.2, David Nemazeez
• MGI ID: MGI:6451773
• Synonyms: Pld4^-
• Gene: Pld4 Location: Chr12:112727089-112735420 bp, + strand Genetic Position: Chr12, 61.2 cM
• Alliance: Pld4^tm1.2Nemz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 6. The neo cassette was removed through subsequent flp-mediated recombination and exons 4-6 were deleted through cre-mediated recombination. Immunohistochemistry showed no peptide is expressed from this allele. (J:281205)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld4 Mutation: 26 strains or lines available

References

• Original: J:281205 Gavin AL, et al., PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953
• All: 2 reference(s)