About   Help   FAQ
Spontaneous Allele Detail
Symbol: Faslpr
Name: Fas cell surface death receptor; lymphoproliferation
MGI ID: MGI:1856334
Synonyms: Fas-, Fas-def, lpr, MRL/lpr, Tnfrf6lpr, Tnfrsf6lpr, Tnfrsf6lpr
Gene: Fas  Location: Chr19:34268066-34305172 bp, + strand  Genetic Position: Chr19, 29.48 cM
Alliance: Faslpr page
control and Faslpr/Faslpr

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  MRL/Mp
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Transposon insertion
Mutation detailsSouthern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within the second intron. Sequencing of genomic DNA and RT-PCR products from homozygous mutant mice revealed the insertion of an early transposable element (ETn) into intron 2. RT-PCR analysis of liver and thymus mRNA showed that the presence of the ETn leads to premature termination of transcription at the long terminal repeat (LTR) of the ETn and aberrant mRNA splicing. The mutation is "leaky," however, as full-length mRNA and a longer splice product incorporating a segment of the ETn as an extra intron are detected in the thymus at low levels. (J:1181, J:4166, J:4342, J:14206, J:14503, J:15429)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 27 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 37 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 39 strains available      Cell Lines: 0 lines available
Carrying any Fas Mutation:  82 strains or lines available
Faslpr, lymphoproliferation, recessive. This mutation was found during inbreeding of a strain MRL/Mp derived from crosses among strains LG, AKR, C3H, and C57BL/6. The resemblance has led to extensive use of Faslpr mice in attempts to determine the etiology of SLE and to evaluate therapies. However, the human APT1 gene (OMIM 134637) encodes the FAS antigen; Tnfrsf6 is not the homolog of the human (SLE) gene. The Cd72c haplotype is a modifier of Faslpr-induced autoimmune disease. J:204782
Original:  J:28885 Murphy ED, et al., Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice, in Genetic Control of Autoimmune Disease. 1978:207-20.
All:  1013 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory