Phenotypes Associated with This Genotype

Genotype
MGI:3623449

• Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts
• Genetic Background: NOD.129S7(B6)-Ifng^tm1Ts/DvsJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

immune system

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

abnormal cytotoxic T cell physiology ( J:72818 )

• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

decreased susceptibility to autoimmune diabetes ( J:72818 )

• when diabetic NOD splenocytes are transferred into mutant NOD mice, only 33% develop diabetes over the course of the observation period

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:72818 )

• islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity

hematopoietic system

abnormal diapedesis ( J:72818 )

• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

abnormal cytotoxic T cell physiology ( J:72818 )

• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:72818